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Non-essential amino acids play an important role in adaptation of the rat exocrine pancreas to high nitrogen feeding.

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Title: Non-essential amino acids play an important role in adaptation of the rat exocrine pancreas to high nitrogen feeding.
Authors: Hara, Hiroshi Browse this author →KAKEN DB
Akatsuka, Naoki Browse this author
Aoyama, Yoritaka Browse this author
Keywords: Dietary amino acids
Non-essential amino acids
Exocrine pancreas
Trypsin
Amylase
Rats
Issue Date: Aug-2001
Publisher: Elsevier Science Inc.
Journal Title: The Journal of Nutritional Biochemistry
Volume: 12
Issue: 8
Start Page: 450
End Page: 457
Publisher DOI: 10.1016/S0955-2863(01)00159-0
PMID: 11834203
Abstract: We have previously demonstrated that feeding a diet with a high amino acid (60% AA diet) content, as a mixture simulating casein, induced pancreatic growth and pancreatic protease production in rats. In the present study, we examined the effects of an increasing dietary content of essential amino acids (EAA, x1 - x3 in exp. 1 and x1 - x3.3 in exp. 2) and non-essential amino acids (NEAA, x1 - x3 in exp. 1 and x1 - x5.2 in exp. 2) on pancreatic growth, amylase and protease adaptation using casein-type amino acid mixtures (exp. 1, basal diet; 20% AA diet) and egg white-type amino acid mixtures (exp. 2, basal diet; 12% AA diet). Pancreatic growth and trypsin activity were induced as the dietary content of NEAA was increased in experiments 1 and 2. Amylase activity in the pancreas was also induced as the dietary content of NEAA was increased, even with the decrease in dietary carbohydrate in experiment 2. The values of all pancreatic variables decreased with the increase in dietary EAA (x2 and x3) without an increase in NEAA. The changes in the pancreas were coincident with increases in plasma arginine and lysine concentrations and a decrease in the plasma alanine concentration. In rats fed a 60% AA diet (EAA and NEAA x3), in the case of which the EAA content was balanced with the NEAA content, pancreatic growth and protease production increased and reached maximum levels as the plasma amino acid concentrations decreased, except for alanine. These results show that NEAA, not EAA, are associated with induction of pancreatic growth and protease production upon feeding a diet with a high AA content, and that some metabolites may be involved in the induction process. The suppression of pancreatic growth and protease production in rats fed the high EAA diets without balanced NEAA may be associated with impairment of amino acid metabolism rather than the increments in the concentration of one or more essential amino acids. Our results also suggest that there is an unknown mechanism or unknown factors involved in regulating pancreatic amylase.
Relation: http://www.sciencedirect.com/science/journal/09552863
Type: article (author version)
URI: http://hdl.handle.net/2115/15872
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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