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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences >
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Growth inhibition and apoptosis induction by all-trans-conjugated linolenic acids on human colon cancer cells
| Title: | Growth inhibition and apoptosis induction by all-trans-conjugated linolenic acids on human colon cancer cells |
| Authors: | Yasui, Y. Browse this author | | Hosokawa, M. Browse this author →KAKEN DB | | Kohno, H. Browse this author | | Tanaka, T. Browse this author | | Miyashita, K. Browse this author |
| Keywords: | Conjugated linolenic acid isomers | | β-eleostearic acid | | β-calendic acid | | growth inhibition | | apoptosis | | Caco-2 cells |
| Issue Date: | 2006 |
| Publisher: | International Institute of Anticancer Research |
| Journal Title: | Anticancer Research |
| Volume: | 26 |
| Issue: | 3A |
| Start Page: | 1855 |
| End Page: | 1860 |
| PMID: | 16827117 |
| Abstract: | Conjugated linolenic acids (CLN) are geometric and positional isomers of linolenic acid. Growth inhibition and apoptosis induction by alpha-eleostearic acid (c9,t11,t13-CLN), beta-eleostearic acid (t9,t11,t13-CLN), alpha-calendic acid (t8,t10,c12-CLN) and beta-calendic acid (t8,t10,t12-CLN) were compared. beta-Eleostearic acid and beta-calendic acid, which have all-trans-conjugated double bonds, exerted stronger growth inhibition and more DNA fragmentation, an indicator of apoptosis induction, in the human colon cancer cells Caco-2 than alpha-eleostearic acid and alpha-calendic acid with the cis configuration. Down-regulation of bcl-2 and up-regulation of bax mRNA by beta-eleostearic acid were also greater than by alpha-eleostearic acid. Interestingly, the cytotoxic effects of beta-eleostearic acid and beta-calendic acid were not counteracted completely by alpha-tocopherol, whereas the cytotoxic effects of alpha-eleostearic and alpha-calendic acids were lost in the presence of alpha-tocopherol. These results suggest that beta-eleostearic and beta-calendic acids have signaling pathways different from those of alpha-eleostearic and alpha-calendic acids and exhibit high potency for reducing the cell viability of Caco-2. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/15886 |
| Appears in Collections: | 水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 細川 雅史
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