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Growth inhibition and apoptosis induction by all-trans-conjugated linolenic acids on human colon cancer cells

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タイトル: Growth inhibition and apoptosis induction by all-trans-conjugated linolenic acids on human colon cancer cells
著者: Yasui, Y. 著作を一覧する
Hosokawa, M. 著作を一覧する
Kohno, H. 著作を一覧する
Tanaka, T. 著作を一覧する
Miyashita, K. 著作を一覧する
キーワード: Conjugated linolenic acid isomers
β-eleostearic acid
β-calendic acid
growth inhibition
apoptosis
Caco-2 cells
発行日: 2006年
出版者: International Institute of Anticancer Research
誌名: Anticancer Research
巻: 26
号: 3A
開始ページ: 1855
終了ページ: 1860
抄録: Conjugated linolenic acids (CLN) are geometric and positional isomers of linolenic acid. Growth inhibition and apoptosis induction by alpha-eleostearic acid (c9,t11,t13-CLN), beta-eleostearic acid (t9,t11,t13-CLN), alpha-calendic acid (t8,t10,c12-CLN) and beta-calendic acid (t8,t10,t12-CLN) were compared. beta-Eleostearic acid and beta-calendic acid, which have all-trans-conjugated double bonds, exerted stronger growth inhibition and more DNA fragmentation, an indicator of apoptosis induction, in the human colon cancer cells Caco-2 than alpha-eleostearic acid and alpha-calendic acid with the cis configuration. Down-regulation of bcl-2 and up-regulation of bax mRNA by beta-eleostearic acid were also greater than by alpha-eleostearic acid. Interestingly, the cytotoxic effects of beta-eleostearic acid and beta-calendic acid were not counteracted completely by alpha-tocopherol, whereas the cytotoxic effects of alpha-eleostearic and alpha-calendic acids were lost in the presence of alpha-tocopherol. These results suggest that beta-eleostearic and beta-calendic acids have signaling pathways different from those of alpha-eleostearic and alpha-calendic acids and exhibit high potency for reducing the cell viability of Caco-2.
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/15886
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 細川 雅史

 

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