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Non-responsiveness to gefitinib in a patient with lung adenocarcinoma having rare EGFR mutations S768I and V769L.

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Title: Non-responsiveness to gefitinib in a patient with lung adenocarcinoma having rare EGFR mutations S768I and V769L.
Authors: Asahina, Hajime Browse this author
Yamazaki, Koichi Browse this author
Kinoshita, Ichiro Browse this author
Yokouchi, Hiroshi Browse this author
Dosaka-Akita, Hirotoshi Browse this author
Nishimura, Masaharu Browse this author
Keywords: Epidermal growth factor receptor (EGFR)
Mutation
Non-small cell lung cancer (NSCLC)
Gefitinib
Chemotherapy
First-line therapy
Issue Date: Dec-2006
Publisher: Elsevier
Journal Title: Lung Cancer
Volume: 54
Issue: 3
Start Page: 419
End Page: 422
Publisher DOI: 10.1016/j.lungcan.2006.09.005
PMID: 17045698
Abstract: Mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) are associated with clinical responsiveness to EGFR-tyrosine kinase inhibitors (EGFR-TKIs) in patients with non-small cell lung cancers (NSCLCs). However, certain rare EGFR mutations including S768I are reported to confer less in vitro sensitivity to gefitinib, an EGFR-TKI, than major mutations such as exon 19 deletions and L858R and even the wild-type counterpart. Here, we report the first case of adenocarcinoma of the lung in which the patient had rare mutations S768I and V769L and was treated with gefitinib. Disease progressed during 6 weeks of treatment. This case suggests that in vitro sensitivity to gefitinib correlates with distinct clinical responsiveness to gefitinib in various types of EGFR mutations.
Relation: http://www.sciencedirect.com/science/journal/01695002
Type: article (author version)
URI: http://hdl.handle.net/2115/17005
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 西村 正治

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