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Non-responsiveness to gefitinib in a patient with lung adenocarcinoma having rare EGFR mutations S768I and V769L.
Title: | Non-responsiveness to gefitinib in a patient with lung adenocarcinoma having rare EGFR mutations S768I and V769L. |
Authors: | Asahina, Hajime Browse this author | Yamazaki, Koichi Browse this author | Kinoshita, Ichiro Browse this author | Yokouchi, Hiroshi Browse this author | Dosaka-Akita, Hirotoshi Browse this author | Nishimura, Masaharu Browse this author |
Keywords: | Epidermal growth factor receptor (EGFR) | Mutation | Non-small cell lung cancer (NSCLC) | Gefitinib | Chemotherapy | First-line therapy |
Issue Date: | Dec-2006 |
Publisher: | Elsevier |
Journal Title: | Lung Cancer |
Volume: | 54 |
Issue: | 3 |
Start Page: | 419 |
End Page: | 422 |
Publisher DOI: | 10.1016/j.lungcan.2006.09.005 |
PMID: | 17045698 |
Abstract: | Mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) are associated with clinical responsiveness to EGFR-tyrosine kinase inhibitors (EGFR-TKIs) in patients with non-small cell lung cancers (NSCLCs). However, certain rare EGFR mutations including S768I are reported to confer less in vitro sensitivity to gefitinib, an EGFR-TKI, than major mutations such as exon 19 deletions and L858R and even the wild-type counterpart. Here, we report the first case of adenocarcinoma of the lung in which the patient had rare mutations S768I and V769L and was treated with gefitinib. Disease progressed during 6 weeks of treatment. This case suggests that in vitro sensitivity to gefitinib correlates with distinct clinical responsiveness to gefitinib in various types of EGFR mutations. |
Relation: | http://www.sciencedirect.com/science/journal/01695002 |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/17005 |
Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 西村 正治
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