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Angiotensin converting enzyme inhibitors attenuated the expression of G-protein coupled receptor kinases in heart failure patients

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Title: Angiotensin converting enzyme inhibitors attenuated the expression of G-protein coupled receptor kinases in heart failure patients
Authors: Oyama, Naotsugu Browse this author
Urasawa, Kazushi Browse this author
Kaneta, Satoshi Browse this author
Sakai, Hidetsugu Browse this author
Saito, Takahiko Browse this author
Takagi, Chika Browse this author
Yoshida, Ichiro Browse this author
Kitabatake, Akira Browse this author
Tsutsui, Hiroyuki Browse this author →KAKEN DB
Keywords: ACE inhibitor
Congestive heart failure
G protein-coupled receptor kinase
Issue Date: Mar-2006
Publisher: The Japanese Circulation Society
Journal Title: Circulation Journal
Volume: 70
Issue: 3
Start Page: 362
End Page: 363
Publisher DOI: 10.1253/circj.70.362
PMID: 16501306
Abstract: Background: There are few biological markers, which strictly show the severity of congestive heart failure (CHF). Methods and Results: Lymphocyte G-protein coupled receptor kinase (GRK) mRNA expression was measured by quantitative reverse transcription-polymerase chain reaction in 15 CHF patients: 5 patients classified as New York Heart Association class-II treated with angiotensin converting enzyme inhibitor (ACEI) (IIA), 5 patients in class-II without ACEI (IIC), and 5 patients in class-III treated with ACEI (IIIA). GRK mRNA level in IIIA was significantly higher than those in IIA (p<0.05). GRK mRNA level in IIA were significantly lower than those in IIC (p<0.05). Conclusions: The expression level of lymphocyte GRK might show the severity of CHF, and ACEI treatment could reduce the level of GRK in CHF patients. (Circ J 2006; 70: 362 - 363)
Type: article (author version)
URI: http://hdl.handle.net/2115/17015
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 筒井 裕之

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