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Chronic beta-adrenergic receptor stimulation enhances the expression of G-Protein coupled receptor kinases, GRK2 and GRK5, in both the heart and peripheral lymphocytes

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Title: Chronic beta-adrenergic receptor stimulation enhances the expression of G-Protein coupled receptor kinases, GRK2 and GRK5, in both the heart and peripheral lymphocytes
Authors: Oyama, Naotsugu Browse this author
Urasawa, Kazushi Browse this author
Kaneta, Satoshi Browse this author
Sakai, Hidetsugu Browse this author
Saito, Takahiko Browse this author
Takagi, Chika Browse this author
Yoshida, Ichiro Browse this author
Kitabatake, Akira Browse this author
Tsutsui, Hiroyuki Browse this author →KAKEN DB
Keywords: Catecholamine
G protein-coupled receptor kinase
Receptor down-regulation
Issue Date: Aug-2005
Publisher: The Japanese Circulation Society
Journal Title: Circulation Journal
Volume: 69
Issue: 8
Start Page: 987
End Page: 990
Publisher DOI: 10.1253/circj.69.987
PMID: 16041172
Abstract: Background: Enhanced expression of G protein-coupled receptor kinase (GRK) has been reported in failing hearts and in the present study the stability of enhanced GRK mRNA expression, and the correlation between the expression level of GRK mRNA in peripheral lymphocytes and in the heart were both evaluated. Methods and Results: Isoproterenol was injected into rats for 2 weeks, and then GRK5 mRNA was assessed by quantitative reverse transcriptase-palymerase chain reaction. An enhanced expression of cardiac GRK5 mRNA was observed even after 4 weeks of recovery. The isoproterenol-induced increased expression of GRK2 and GRK5 mRNA was equally observed in the heart and lymphocytes, and there was a close correlation between the heart and lymphocytes in the level of expression of each GRK mRNA. Conclusions: The GRK mRNA level is maintained at a high level for a long period without continuous β-adrenergic receptor stimulation. The level in circulating lymphocytes could be used as a surrogate marker to estimate the level of cardiac GRK expression and, presumably, the β-adrenergic receptor function of cardiomyocytes. (Circ J 2005; 69: 987-990)
Type: article (author version)
URI: http://hdl.handle.net/2115/17016
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 筒井 裕之

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