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Extracellular matrix metalloproteinase inducer is increased in smokers' bronchoalveolar lavage fluid.

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Title: Extracellular matrix metalloproteinase inducer is increased in smokers' bronchoalveolar lavage fluid.
Authors: Betsuyaku, Tomoko Browse this author
Tanino, Mishie Browse this author
Nagai, Katsura Browse this author
Nasuhara, Yasuyuki Browse this author →KAKEN DB
Nishimura, Masaharu Browse this author →KAKEN DB
Senior, Robert M. Browse this author
Keywords: smoking
emphysema
matrix metalloproteinases
alveolar macrophages
Issue Date: 15-Jul-2003
Publisher: American Thoracic Society
Journal Title: American Journal of Respiratory and Critical Care Medicine
Volume: 168
Issue: 2
Start Page: 222
End Page: 227
Publisher DOI: 10.1164/rccm.200301-103OC
PMID: 12714350
Abstract: Extracellular matrix metalloproteinase inducer (EMMPRIN), also called basigin, is present in the lung during development, but its expression in normal adult lung is minimal. Increases of EMMPRIN have been found in various forms of experimental lung injury. To determine whether EMMPRIN might be involved in alveolar injury/repair associated with smoking, we developed an ELISA for EMMPRIN and applied it to bronchoalveolar lavage fluids from never-smokers (n = 7), former smokers (n = 16), and current smokers (n = 58). The smoker groups included subjects with emphysema, as determined by high-resolution chest computed tomography. EMMPRIN levels were significantly elevated in current and former smokers (315 ± 20 and 175 ± 15 pg/ml SEM, respectively, compared with 31 ± 7 pg/ml in never-smokers), but the EMMPRIN levels of smokers with emphysema were not different from smokers without emphysema. Immunohistochemistry of smokers' lung tissue showed EMMPRIN in bronchiolar epithelium and alveolar macrophages, but EMMPRIN mRNA in alveolar macrophages was not different between current and never-smokers. Matrix metalloproteinase-1 was also detectable in the bronchoalveolar lavage fluid from some smokers but not in never-smokers. These findings indicate that smoking is associated with increased intrapulmonary EMMPRIN. Whether EMMPRIN is involved in smoking-induced lung pathology remains to be determined.
Relation: http://ajrccm.atsjournals.org/
Type: article
URI: http://hdl.handle.net/2115/17089
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 別役 智子

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