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A common FCER1B gene promoter polymorphism influences total serum IgE levels in a Japanese population.

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Title: A common FCER1B gene promoter polymorphism influences total serum IgE levels in a Japanese population.
Authors: Hizawa, Nobuyuki Browse this author
Yamaguchi, Etsuro Browse this author
Jinushi, Eisei Browse this author
Kawakami, Yoshikazu Browse this author
Issue Date: Mar-2000
Publisher: American Thoracic Society
Journal Title: American Journal of Respiratory and Critical Care Medicine
Volume: 161
Issue: 3
Start Page: 906
End Page: 909
Publisher DOI: 10.1164/ajrccm.161.3.9903128
PMID: 10712341
Abstract: Genetic factors are important in defining total serum IgE levels. Linkage analyses have localized a gene or genes that influence atopic phenotype at chromosome 11q13. Variants of the FCER1B gene have been identified, which are associated with an increased risk of developing atopy and bronchial asthma. Given uncertain functional consequences and low frequencies of these coding variants of FCER1B, we screened for new mutations using 24 subjects with atopic asthma. A common 109C/T polymorphism at the promoter region of FCER1B was identified, although no variant was found in the entire coding region. We genotyped this promoter polymorphism in 226 healthy control subjects and 226 asthmatic subjects using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Allele frequencies were 0.697 for 109T and 0.303 for 109C in 226 healthy control subjects. No significant difference in the distribution of 109C/T polymorphism was found between asthmatic subjects and healthy control subjects. A homozygosity for the 109T allele, however, was associated with increased total serum IgE levels in 226 subjects with asthma (p = 0.0015). The strongest evidence for an association between total serum IgE levels and 109C/T polymorphism (p = 0.0004) was obtained when age at onset of asthma was incorporated into the analysis. Our findings may represent genetic heterogeneity and complex interactions between genetic and environmental components involved in the regulation of total IgE levels, providing evidence that the 109C/T polymorphism of the FCER1B promoter region is one of the genetic factors identified thus far, which affects total serum IgE levels in a Japanese population. Hizawa N, Yamaguchi E, Jinushi E, Kawakami Y. A common FCER1B gene promoter polymorphism influences total serum IgE levels in a Japanese population.
Rights: http://ajrccm.atsjournals.org/
Type: article
URI: http://hdl.handle.net/2115/17092
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 檜澤 伸之

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