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Airflow limitation and airway dimensions in chronic obstructive pulmonary disease.

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タイトル: Airflow limitation and airway dimensions in chronic obstructive pulmonary disease.
著者: Hasegawa, Masaru 著作を一覧する
Nasuhara, Yasuyuki 著作を一覧する
Onodera, Yuya 著作を一覧する
Makita, Hironi 著作を一覧する
Nagai, Katsura 著作を一覧する
Fuke, Satoshi 著作を一覧する
Ito, Yoko 著作を一覧する
Betsuyaku, Tomoko 著作を一覧する
Nishimura, Masaharu 著作を一覧する
キーワード: airway luminal area
airway wall
computed tomography
multiplanar reconstruction
small airway
発行日: 2006年 6月15日
出版者: American Thoracic Society
誌名: American Journal of Respiratory and Critical Care Medicine
巻: 173
号: 12
開始ページ: 1309
終了ページ: 1315
出版社 DOI: 10.1164/rccm.200601-037OC
抄録: Rationale: Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation caused by emphysema and/or airway narrowing. Computed tomography has been widely used to assess emphysema severity, but less attention has been paid to the assessment of airway disease using computed tomography. Objectives: To obtain longitudinal images and accurately analyze short axis images of airways with an inner diameter 2 mm located anywhere in the lung with new software for measuring airway dimensions using curved multiplanar reconstruction. Methods: In 52 patients with clinically stable COPD (stage I, 14; stage II, 22; stage III, 14; stage IV, 2), we used the software to analyze the relationship of the airflow limitation index (FEV1, % predicted) with the airway dimensions from the third to the sixth generations of the apical bronchus (B1) of the right upper lobe and the anterior basal bronchus (B8) of the right lower lobe. Measurements and Main Results: Airway luminal area (Ai) and wall area percent (WA%) were significantly correlated with FEV1 (% predicted). More importantly, the correlation coefficients (r) improved as the airways became smaller in size from the third (segmental) to sixth generations in both bronchi (Ai: r = 0.26, 0.37, 0.58, and 0.64 for B1; r = 0.60, 0.65, 0.63, and 0.73 for B8). Conclusions: We are the first to use three-dimensional computed tomography to demonstrate that airflow limitation in COPD is more closely related to the dimensions of the distal (small) airways than proximal (large) airways.
資料タイプ: article
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 西村 正治


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