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Airflow limitation and airway dimensions in chronic obstructive pulmonary disease.

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Title: Airflow limitation and airway dimensions in chronic obstructive pulmonary disease.
Authors: Hasegawa, Masaru Browse this author
Nasuhara, Yasuyuki Browse this author →KAKEN DB
Onodera, Yuya Browse this author
Makita, Hironi Browse this author
Nagai, Katsura Browse this author
Fuke, Satoshi Browse this author
Ito, Yoko Browse this author
Betsuyaku, Tomoko Browse this author →KAKEN DB
Nishimura, Masaharu Browse this author →KAKEN DB
Keywords: airway luminal area
airway wall
computed tomography
multiplanar reconstruction
small airway
Issue Date: 15-Jun-2006
Publisher: American Thoracic Society
Journal Title: American Journal of Respiratory and Critical Care Medicine
Volume: 173
Issue: 12
Start Page: 1309
End Page: 1315
Publisher DOI: 10.1164/rccm.200601-037OC
PMID: 16556695
Abstract: Rationale: Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation caused by emphysema and/or airway narrowing. Computed tomography has been widely used to assess emphysema severity, but less attention has been paid to the assessment of airway disease using computed tomography. Objectives: To obtain longitudinal images and accurately analyze short axis images of airways with an inner diameter 2 mm located anywhere in the lung with new software for measuring airway dimensions using curved multiplanar reconstruction. Methods: In 52 patients with clinically stable COPD (stage I, 14; stage II, 22; stage III, 14; stage IV, 2), we used the software to analyze the relationship of the airflow limitation index (FEV1, % predicted) with the airway dimensions from the third to the sixth generations of the apical bronchus (B1) of the right upper lobe and the anterior basal bronchus (B8) of the right lower lobe. Measurements and Main Results: Airway luminal area (Ai) and wall area percent (WA%) were significantly correlated with FEV1 (% predicted). More importantly, the correlation coefficients (r) improved as the airways became smaller in size from the third (segmental) to sixth generations in both bronchi (Ai: r = 0.26, 0.37, 0.58, and 0.64 for B1; r = 0.60, 0.65, 0.63, and 0.73 for B8). Conclusions: We are the first to use three-dimensional computed tomography to demonstrate that airflow limitation in COPD is more closely related to the dimensions of the distal (small) airways than proximal (large) airways.
Relation: http://ajrccm.atsjournals.org/
Type: article
URI: http://hdl.handle.net/2115/17093
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 西村 正治

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