|Title: ||Airflow limitation and airway dimensions in chronic obstructive pulmonary disease.|
|Authors: ||Hasegawa, Masaru Browse this author|
|Nasuhara, Yasuyuki Browse this author →KAKEN DB|
|Onodera, Yuya Browse this author|
|Makita, Hironi Browse this author|
|Nagai, Katsura Browse this author|
|Fuke, Satoshi Browse this author|
|Ito, Yoko Browse this author|
|Betsuyaku, Tomoko Browse this author →KAKEN DB|
|Nishimura, Masaharu Browse this author →KAKEN DB|
|Keywords: ||airway luminal area|
|Issue Date: ||15-Jun-2006|
|Publisher: ||American Thoracic Society|
|Journal Title: ||American Journal of Respiratory and Critical Care Medicine|
|Start Page: ||1309|
|End Page: ||1315|
|Publisher DOI: ||10.1164/rccm.200601-037OC|
|Abstract: ||Rationale: Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation caused by emphysema and/or airway narrowing. Computed tomography has been widely used to assess emphysema severity, but less attention has been paid to the assessment of airway disease using computed tomography.
Objectives: To obtain longitudinal images and accurately analyze short axis images of airways with an inner diameter 2 mm located anywhere in the lung with new software for measuring airway dimensions using curved multiplanar reconstruction.
Methods: In 52 patients with clinically stable COPD (stage I, 14; stage II, 22; stage III, 14; stage IV, 2), we used the software to analyze the relationship of the airflow limitation index (FEV1, % predicted) with the airway dimensions from the third to the sixth generations of the apical bronchus (B1) of the right upper lobe and the anterior basal bronchus (B8) of the right lower lobe.
Measurements and Main Results: Airway luminal area (Ai) and wall area percent (WA%) were significantly correlated with FEV1 (% predicted). More importantly, the correlation coefficients (r) improved as the airways became smaller in size from the third (segmental) to sixth generations in both bronchi (Ai: r = 0.26, 0.37, 0.58, and 0.64 for B1; r = 0.60, 0.65, 0.63, and 0.73 for B8).
Conclusions: We are the first to use three-dimensional computed tomography to demonstrate that airflow limitation in COPD is more closely related to the dimensions of the distal (small) airways than proximal (large) airways.|
|Appears in Collections:||医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)|