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Bronchoscopic microsampling method for measuring drug concentration in epithelial lining fluid

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Title: Bronchoscopic microsampling method for measuring drug concentration in epithelial lining fluid
Authors: Yamazaki, Koichi Browse this author
Ogura, Shigeaki. Browse this author
Ishizaka, Akitoshi Browse this author
Oh-hara, Toshinari Browse this author
Nishimura, Masaharu Browse this author →KAKEN DB
Keywords: bronchoscopy
antimicrobial agents
respiratory tract infection
time versus concentration profile
Issue Date: 1-Dec-2003
Publisher: American Thoracic Society
Journal Title: American Journal of Respiratory and Critical Care Medicine
Volume: 168
Issue: 11
Start Page: 1304
End Page: 1307
Publisher DOI: 10.1164/rccm.200301-111OC
PMID: 12904323
Abstract: Direct measurement of the concentration of antimicrobial agents in bronchial epithelial lining fluid (ELF) would allow for a more informed approach to appropriate dosing of antimicrobial agents for respiratory tract infections. In this study, we determined the time versus concentration profile in ELF after an oral administration of levofloxacin, using recently developed bronchoscopic microsampling probes. These probes could be repeatedly and safely inserted through the fiberoptic bronchoscope in normal healthy volunteers. The concentration of levofloxacin in ELF was 43.4% of the corresponding serum value at 1 hour, reached the same level at 2 hours, decreased in a similar manner as that in serum, and returned to undetectable levels at 24 hours. It exceeded minimal inhibitory concentrations of Staphylococcus aureus (0.25 µg/ml), Klebsiella species (0.5 µg/ml), and Haemophilus influenzae (0.06 µg/ml) after 6 hours. The experimental procedure was well tolerated, and no complications were observed. In conclusion, bronchoscopic microsampling is a feasible and promising method for measuring antimicrobial concentrations in the target sites of respiratory tracts directly and repeatedly.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 山崎 浩一

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