|
Hokkaido University Collection of Scholarly and Academic Papers >
Hokkaido University Hospital >
Peer-reviewed Journal Articles, etc >
N-Linked neutral oligosaccharides in the stratum corneum of normal and ichthyotic skin
| Title: | N-Linked neutral oligosaccharides in the stratum corneum of normal and ichthyotic skin |
| Authors: | Ito, Hiroko Browse this author | | Akiyama, Masashi Browse this author | | Nakagawa, Hiroaki Browse this author | | Uematsu, Rie Browse this author | | Deguchi, Kisaburo Browse this author | | McMillan, James R. Browse this author | | Nishimura, Shin-Ichiro Browse this author →KAKEN DB | | Shimizu, Hiroshi Browse this author →KAKEN DB |
| Keywords: | High-performance liquid chromatography | | Hyperkeratosis | | Neutral oligosaccharide | | N-Glycan | | Oligosaccharide |
| Issue Date: | Jan-2007 |
| Publisher: | Springer |
| Journal Title: | Archives of Dermatological Research |
| Volume: | 298 |
| Issue: | 8 |
| Start Page: | 403 |
| End Page: | 407 |
| Publisher DOI: | 10.1007/s00403-006-0702-0 |
| PMID: | 17021764 |
| Abstract: | N-Glycan oligosaccharides are thought to play multiple, important roles in a variety of biological events. However, N-glycan profiles in the stratum corneum of human skin have not yet been studied in detail. To clarify the N-glycan profiles in the stratum corneum of normal and ichthyotic epidermis, N-glycan profiles were studied by high-performance liquid chromatography using normal human epidermal samples and scales from hyperkeratotic skin of ichthyosis patients. Chromatograms of patient scale samples showed unique alterations in three peaks eluted at 15.8, 18.8 and 26.9 min. The N-glycan profiles were significantly altered in ichthyotic hyperkeratotic skin compared with normal non-hyperkeratotic controls. These findings indicate the reduction of N-acetylglucosaminyltransferase II and fucosyltransferase 8 activities. Alteration of N-glycan structures in hyperkeratotic skin suggests the biological role of N-glycans in keratinization. |
| Rights: | The original publication is available at www.springerlink.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/17126 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 秋山 真志
|
