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N-Linked neutral oligosaccharides in the stratum corneum of normal and ichthyotic skin

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Title: N-Linked neutral oligosaccharides in the stratum corneum of normal and ichthyotic skin
Authors: Ito, Hiroko Browse this author
Akiyama, Masashi Browse this author
Nakagawa, Hiroaki Browse this author
Uematsu, Rie Browse this author
Deguchi, Kisaburo Browse this author
McMillan, James R. Browse this author
Nishimura, Shin-Ichiro Browse this author
Shimizu, Hiroshi Browse this author
Keywords: High-performance liquid chromatography
Neutral oligosaccharide
Issue Date: Jan-2007
Publisher: Springer
Journal Title: Archives of Dermatological Research
Volume: 298
Issue: 8
Start Page: 403
End Page: 407
Publisher DOI: 10.1007/s00403-006-0702-0
Abstract: N-Glycan oligosaccharides are thought to play multiple, important roles in a variety of biological events. However, N-glycan profiles in the stratum corneum of human skin have not yet been studied in detail. To clarify the N-glycan profiles in the stratum corneum of normal and ichthyotic epidermis, N-glycan profiles were studied by high-performance liquid chromatography using normal human epidermal samples and scales from hyperkeratotic skin of ichthyosis patients. Chromatograms of patient scale samples showed unique alterations in three peaks eluted at 15.8, 18.8 and 26.9 min. The N-glycan profiles were significantly altered in ichthyotic hyperkeratotic skin compared with normal non-hyperkeratotic controls. These findings indicate the reduction of N-acetylglucosaminyltransferase II and fucosyltransferase 8 activities. Alteration of N-glycan structures in hyperkeratotic skin suggests the biological role of N-glycans in keratinization.
Rights: The original publication is available at
Type: article (author version)
Appears in Collections:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 秋山 真志


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