Developmental localization of potassium chloride co-transporter 2 (KCC2) in the Purkinje cells of embryonic mouse cerebellum


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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/17166

Title:	Developmental localization of potassium chloride co-transporter 2 (KCC2) in the Purkinje cells of embryonic mouse cerebellum
Authors:	Takayama, Chitoshi Browse this author →KAKEN DB
Authors:	Inoue, Yoshiro Browse this author →KAKEN DB
Keywords:	NKCC1
	GABA
	Synaptophysin
	Vesicular GABA transporter
	Climbing fiber
Issue Date:	Feb-2007
Publisher:	Elsevier Ireland Ltd
Journal Title:	Neuroscience Research
Volume:	57
Issue:	2
Start Page:	322
End Page:	325
Publisher DOI:	10.1016/j.neures.2006.10.016
PMID:	17134779
Abstract:	Developmental shift in GABA actions from depolarization to hyperpolarization occurs as a result of decreasing the intracellular Cl− concentration regulated by K+-Cl− co-transporter 2 (KCC2). To clarify the time-course of the developmental shift on the Purkinje cells, we examined KCC2-localization in the embryonic mouse cerebellum. The KCC2 was first detected within the Purkinje cells in the Purkinje cell layer of the hemisphere at embryonic day 15 (E15) and the vermis at E17, but the ventricular and intermediate zones were negative. These results suggest that GABA might become inhibitory on the Purkinje cells after their settling in the Purkinje cell layer.
Relation:	http://www.sciencedirect.com/science/journal/01680102
Type:	article (author version)
URI:	http://hdl.handle.net/2115/17166
Appears in Collections:	医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 高山千利

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