HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
医学研究院・医学院  >
雑誌発表論文等  >

Developmental localization of potassium chloride co-transporter 2 (KCC2) in the Purkinje cells of embryonic mouse cerebellum

フルテキスト
NR2006.pdf1.35 MBPDF見る/開く
この文献へのリンクには次のURLを使用してください:http://hdl.handle.net/2115/17166

タイトル: Developmental localization of potassium chloride co-transporter 2 (KCC2) in the Purkinje cells of embryonic mouse cerebellum
著者: Takayama, Chitoshi 著作を一覧する
Inoue, Yoshiro 著作を一覧する
キーワード: NKCC1
GABA
Synaptophysin
Vesicular GABA transporter
Climbing fiber
発行日: 2007年 2月
出版者: Elsevier Ireland Ltd
誌名: Neuroscience Research
巻: 57
号: 2
開始ページ: 322
終了ページ: 325
出版社 DOI: 10.1016/j.neures.2006.10.016
抄録: Developmental shift in GABA actions from depolarization to hyperpolarization occurs as a result of decreasing the intracellular Cl− concentration regulated by K+-Cl− co-transporter 2 (KCC2). To clarify the time-course of the developmental shift on the Purkinje cells, we examined KCC2-localization in the embryonic mouse cerebellum. The KCC2 was first detected within the Purkinje cells in the Purkinje cell layer of the hemisphere at embryonic day 15 (E15) and the vermis at E17, but the ventricular and intermediate zones were negative. These results suggest that GABA might become inhibitory on the Purkinje cells after their settling in the Purkinje cell layer.
関連URI: http://www.sciencedirect.com/science/journal/01680102
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/17166
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 高山 千利

 

本サイトに関するご意見・お問い合わせは repo at lib.hokudai.ac.jp へお願いします。 - 北海道大学