HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Hokkaido University Hospital >
Peer-reviewed Journal Articles, etc >

Relationship between preexisting anti-varicella-zoster virus (VZV) antibody and clinical VZV reactivation in hematopoietic stem cell transplantation recipients.

Files in This Item:
JCM44-12.pdf100.16 kBPDFView/Open
Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/17172

Title: Relationship between preexisting anti-varicella-zoster virus (VZV) antibody and clinical VZV reactivation in hematopoietic stem cell transplantation recipients.
Authors: Onozawa, Masahiro Browse this author
Hashino, Satoshi Browse this author →KAKEN DB
Takahata, Mutsumi Browse this author
Fujisawa, Fumie Browse this author
Kawamura, Takahito Browse this author
Nakagawa, Masao Browse this author
Kahata, Kaoru Browse this author
Kondo, Takeshi Browse this author →KAKEN DB
Ota, Shuichi Browse this author
Tanaka, Junji Browse this author
Imamura, Masahiro Browse this author
Asaka, Masahiro Browse this author
Issue Date: Dec-2006
Publisher: the American Society for Microbiology
Journal Title: Journal of Clinical Microbiology
Volume: 44
Issue: 12
Start Page: 4441
End Page: 4443
Publisher DOI: 10.1128/JCM.01312-06
PMID: 17035500
Abstract: Reactivation of latent varicella zoster virus (VZV), presenting as localized zoster or as disseminated infection, is a common and potentially serious complication in hematopoietic stem cell transplantation (HSCT) recipients. We retrospectively studied anti-VZV IgG titers by the immune adherence hemagglutination method after HSCT and VZV DNA by real-time PCR during clinical VZV reactivation using cryopreserved serum samples. No significant difference was found between anti-VZV titers in 13 patients with VZV infection (localized zoster in 11 patients and disseminated zoster in 2 patients) and those in 13 subjects without VZV infection at each time point after HSCT. Pre-existing anti-VZV titers of disseminated zoster cases tended to be lower than those of localized zoster cases (P=0.10). Serum VZV-DNA copy numbers at onset of disseminated zoster cases tended to be higher than those of localized zoster cases (P=0.09). A strong inverse correlation was found between pre-existing anti-VZV titer and serum VZV-DNA at onset (r=-0.90, P=0.006). In HSCT recipients, pre-existing antibody does not prevent development of VZV reactivation but may contribute to decreased viral load at onset, resulting in a mild clinical course.
Rights: Copyright © American Society for Microbiology
Type: article (author version)
URI: http://hdl.handle.net/2115/17172
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 小野澤 真弘

Export metadata:

OAI-PMH ( junii2 , jpcoar )


 

Feedback - Hokkaido University