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A case of myelodysplastic syndrome developed blastic crisis of chronic myelogenous leukemia with acquisition of major BCR/ABL

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タイトル: A case of myelodysplastic syndrome developed blastic crisis of chronic myelogenous leukemia with acquisition of major BCR/ABL
著者: Onozawa, Masahiro 著作を一覧する
Fukuhara, Takashi 著作を一覧する
Takahata, Mutsumi 著作を一覧する
Yamamoto, Yasushi 著作を一覧する
Miyake, Takayoshi 著作を一覧する
Maekawa, Isao 著作を一覧する
キーワード: Myelodysplastic syndrome
Philadelphia chromosome
Major BCR/ABL
Blastic crisis
Imatinib mesylate
発行日: 2003年 9月
出版者: Springer Berlin / Heidelberg
誌名: Annals of Hematology
巻: 82
号: 9
開始ページ: 593
終了ページ: 595
出版社 DOI: 10.1007/s00277-003-0703-4
抄録: We describe a rare case of myelodysplastic syndrome that developed chronic myelogeneous leukemia with acquisition of Philadelphia chromosome. The major BCR/ABL transcript was confirmed by molecular analysis. Shortly thereafter, the patient showed transformation to blastic crisis. Hematological remission was achieved after 3 months of treatment with imatinib mesylate. The patient relapsed with additional chromosomal abnormalities and the disease became refractory to the treatment. Acquisition of the Philadelphia chromosome is an infrequent event in myelodysplastic syndrome, and the addition of this change to the initial genetic abnormality that caused MDS may have been associated with the accelerated clinical course of this patient.
Rights: The original publication is available at www.springerlink.com
Relation (URI): http://www.springerlink.com
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/17240
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 小野澤 真弘

 

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