A case of myelodysplastic syndrome developed blastic crisis of chronic myelogenous leukemia with acquisition of major BCR/ABL

Onozawa, Masahiro; Fukuhara, Takashi; Takahata, Mutsumi; Yamamoto, Yasushi; Miyake, Takayoshi; Maekawa, Isao

doi:10.1007/s00277-003-0703-4


Hokkaido University \| Library \| HUSCAP	Advanced Search		言語

	Home
	About HUSCAP
	Open Access Policy

	Browse by Author

Browse
	Communities & Collections

	Scholarly Journals
	Theses
	Doctoral Dissertations Listed by Graduate Schools
	Conference Procs.
	Events

	HUSCAP Senior (in Japanese)

	Societies

	Downloads (country)

For university staff
	How to post your papers to HUSCAP
	Publication of theses
	Helpline about theses publication

Open Archives Compliant

You can search our collection also at:
	Google
	Google Scholar
	CiNii
	IRDB
	OAIster
	NDLTD

Hokkaido University Collection of Scholarly and Academic Papers >
Hokkaido University Hospital >
Peer-reviewed Journal Articles, etc >

A case of myelodysplastic syndrome developed blastic crisis of chronic myelogenous leukemia with acquisition of major BCR/ABL

Files in This Item:

AH82-9.pdf

96.33 kB

PDF

View/Open

Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/17240

Title:	A case of myelodysplastic syndrome developed blastic crisis of chronic myelogenous leukemia with acquisition of major BCR/ABL
Authors:	Onozawa, Masahiro Browse this author
	Fukuhara, Takashi Browse this author
	Takahata, Mutsumi Browse this author
	Yamamoto, Yasushi Browse this author
	Miyake, Takayoshi Browse this author
	Maekawa, Isao Browse this author
Keywords:	Myelodysplastic syndrome
	Philadelphia chromosome
	Major BCR/ABL
	Blastic crisis
	Imatinib mesylate
Issue Date:	Sep-2003
Publisher:	Springer Berlin / Heidelberg
Journal Title:	Annals of Hematology
Volume:	82
Issue:	9
Start Page:	593
End Page:	595
Publisher DOI:	10.1007/s00277-003-0703-4
PMID:	12898186
Abstract:	We describe a rare case of myelodysplastic syndrome that developed chronic myelogeneous leukemia with acquisition of Philadelphia chromosome. The major BCR/ABL transcript was confirmed by molecular analysis. Shortly thereafter, the patient showed transformation to blastic crisis. Hematological remission was achieved after 3 months of treatment with imatinib mesylate. The patient relapsed with additional chromosomal abnormalities and the disease became refractory to the treatment. Acquisition of the Philadelphia chromosome is an infrequent event in myelodysplastic syndrome, and the addition of this change to the initial genetic abnormality that caused MDS may have been associated with the accelerated clinical course of this patient.
Rights:	The original publication is available at www.springerlink.com
Relation:	http://www.springerlink.com
Type:	article (author version)
URI:	http://hdl.handle.net/2115/17240
Appears in Collections:	北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 小野澤真弘

OAI-PMH ( junii2 , jpcoar_1.0 )

- Hokkaido University