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A case of myelodysplastic syndrome developed blastic crisis of chronic myelogenous leukemia with acquisition of major BCR/ABL

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Title: A case of myelodysplastic syndrome developed blastic crisis of chronic myelogenous leukemia with acquisition of major BCR/ABL
Authors: Onozawa, Masahiro Browse this author
Fukuhara, Takashi Browse this author
Takahata, Mutsumi Browse this author
Yamamoto, Yasushi Browse this author
Miyake, Takayoshi Browse this author
Maekawa, Isao Browse this author
Keywords: Myelodysplastic syndrome
Philadelphia chromosome
Major BCR/ABL
Blastic crisis
Imatinib mesylate
Issue Date: Sep-2003
Publisher: Springer Berlin / Heidelberg
Journal Title: Annals of Hematology
Volume: 82
Issue: 9
Start Page: 593
End Page: 595
Publisher DOI: 10.1007/s00277-003-0703-4
PMID: 12898186
Abstract: We describe a rare case of myelodysplastic syndrome that developed chronic myelogeneous leukemia with acquisition of Philadelphia chromosome. The major BCR/ABL transcript was confirmed by molecular analysis. Shortly thereafter, the patient showed transformation to blastic crisis. Hematological remission was achieved after 3 months of treatment with imatinib mesylate. The patient relapsed with additional chromosomal abnormalities and the disease became refractory to the treatment. Acquisition of the Philadelphia chromosome is an infrequent event in myelodysplastic syndrome, and the addition of this change to the initial genetic abnormality that caused MDS may have been associated with the accelerated clinical course of this patient.
Rights: The original publication is available at www.springerlink.com
Relation: http://www.springerlink.com
Type: article (author version)
URI: http://hdl.handle.net/2115/17240
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 小野澤 真弘

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