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Volume 11, Number 4 >

ANTITOXOPLASMIC EFFECT OF IMMUNE SWINE SERUM REVEALED IN THE CULTURE OF SWINE LEUKOCYTES

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Please use this identifier to cite or link to this item:https://doi.org/10.14943/jjvr.11.4.135

Title: ANTITOXOPLASMIC EFFECT OF IMMUNE SWINE SERUM REVEALED IN THE CULTURE OF SWINE LEUKOCYTES
Authors: YANAGAWA, Ryo Browse this author
HIRATO, Katsushichi Browse this author
Issue Date: Dec-1963
Publisher: The Graduate School of Veterinary Medicine
Journal Title: Japanese Journal of Veterinary Research
Volume: 11
Issue: 4
Start Page: 135
End Page: 142
Abstract: Samples of buffy coat obtained from pigs actively immunized with Toxoplasma gondii and from a normal pig were cultivated separately in immune and normal swine sera, and the multiplication of toxoplasms in these cultures was studied. In the presence of immune serum, multiplication of toxoplasms was inhibited. The inhibition by immune serum was observed in the cultures of leukocytes derived from both immunized and normal pigs. On the contrary, in the presence of normal serum, toxoplasms multiplied abundantly in the cultures of leukocytes derived from immunized and normal pigs. These findings suggest that circulating immune substances will play a leading role in immunity against toxoplasmosis. The antitoxoplasmic effect of immune serum hardly reached to toxoplasms which had previously penetrated inside leukocytes. The antitoxoplasmic effect shown in the present study proved to be heat-stable, thus was considered different from the neutralizing antibody reported by SABIN and OLITZKY. However, the difference between the two is not yet elucidated.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/1784
Appears in Collections:Japanese Journal of Veterinary Research > Volume 11, Number 4

Submitter: 獣医学部図書室

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