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Volume 13, Number 4 >

STUDIES ON ECHINOCOCCOSIS XVI : EFFECTS OF DRUGS UPON SCOLICES AND DAUGHTER CYSTS OF ECHINOCOCCUS MULTILOCULARIS IN VITRO

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.13.4.127

Title: STUDIES ON ECHINOCOCCOSIS XVI : EFFECTS OF DRUGS UPON SCOLICES AND DAUGHTER CYSTS OF ECHINOCOCCUS MULTILOCULARIS IN VITRO
Authors: SAKAMOTO, Tsukasa Browse this author
YAMASHITA, Jiro Browse this author
OHBAYASHI, Masashi Browse this author
ORIHARA, Miyoji Browse this author
Issue Date: Dec-1965
Publisher: The Graduate School of Veterinary Medicine
Journal Title: Japanese Journal of Veterinary Research
Volume: 13
Issue: 4
Start Page: 127
End Page: 136
Abstract: The morphological changes of scolices and daughter cysts of Echinococcus multilocularis obtained experimentally from infected cotton rats were investigated cytopathologically by use of routine and phase contrast microscopes and supravital staining with neutral red and Janus green. Degenerative changes were recognized distinctly in parenchymal cells of scolices and germinal cells of daughter cyst. The regressive change was accepted as an indication of degeneration of the scolices and daughter cysts in addition to the abnormal changes of themselves. The scolices and daughter cysts were incubated in the medium consisting essentially of 20% bovine serum in medium 199 to which-methyridine, diethylcarbamazine citrate, chloroquine-diphosphate, dl-cupric methionate, sodium antimony-III-biscatechol-2,4-sodium disulfate, sodium antimonyl tartrate and dithiazanine iodide-were added at the rates of 10,40 and 100γ per ml. These scolices and daughter cysts were investigated for 10 days and following results were obtained. Sodium antimonyl tartrate, sodium antimony-III-biscatechol-2,4-sodium disulfonate and dithiazanine iodide manifested the comparatively stronger effects, the decrease of effects was recognized in order as dl-cupric methionate, chloroquine-diphosphate and diethylcarbamazine and methyridine showed the lowest effect, and the highest rate of vesiculated scolices was recognized in the medium with methyridine.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/1830
Appears in Collections:Japanese Journal of Veterinary Research > Volume 13, Number 4

Submitter: 獣医学部図書室

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