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Volume 14, Number 3-4 >

NEUTRALIZATION OF TOXOPLASMS WITH SPECIAL REFERENCE TO THEIR INTRA- AND EXTRACELLULAR LOCALIZATION

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この文献には次のDOIがあります:http://doi.org/10.14943/jjvr.14.3-4.91

タイトル: NEUTRALIZATION OF TOXOPLASMS WITH SPECIAL REFERENCE TO THEIR INTRA- AND EXTRACELLULAR LOCALIZATION
著者: IWASAKI, Naoko 著作を一覧する
YANAGAWA, Ryo 著作を一覧する
発行日: 1966年12月
出版者: The Graduate School of Veterinary Medicine
誌名: Japanese Journal of Veterinary Research
巻: 14
号: 3-4
開始ページ: 91
終了ページ: 102
抄録: Neutralization in vitro of toxoplasms was investigated paying special attention to their intra- and extracellular localization. Toxoplasms were obtained from the ascites of infected mice. To detect the neutralization effect, mice were used as experimental animals, the subcutaneous route of inoculation proved to be successful. Inactivated immune rabbit serum neutralized extracellular, but not intracellular toxoplasms. Addition of fresh human serum to the neutralization system decreased the number of intracellular toxoplasms resulting in a considerable acceleration of neutralizing effect. This finding was investigated and the authors found that this was due to the cytolytic action of human serum on mouse ascitic cells containing toxoplasma intracellularly. The lysis of mouse ascitic cells by human serum was proved by microscopic examinations and also by demonstrating the loss of cell nucleotide. It is to be emphasized that toxoplasms could be neutralized by heat stable specific antibody, in accordance with the previous report of YANAGAWA & HIRATO (1963).
資料タイプ: bulletin
URI: http://hdl.handle.net/2115/1843
出現コレクション:Volume 14, Number 3-4

 

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