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Aberrant Expression of HOX Genes in Oral Dysplasia and Squamous Cell Carcinoma Tissues

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Title: Aberrant Expression of HOX Genes in Oral Dysplasia and Squamous Cell Carcinoma Tissues
Authors: Hassan, Nur Mohammad Monsur Browse this author
Hamada, Jun-ichi Browse this author
Murai, Taichi Browse this author
Seino, Akihusa Browse this author
Takahashi, Yoko Browse this author
Tada, Mitsuhiro Browse this author
Zhang, Xiuru Browse this author
Kashiwazaki, Haruhiko Browse this author
Yamazaki, Yutaka Browse this author →KAKEN DB
Inoue, Nobuo Browse this author
Moriuchi, Tetsuya Browse this author
Keywords: HOX
Oral squamous carcinoma
Oral mucosa
Issue Date: 2006
Publisher: Cognizant Communication Corporation
Journal Title: Oncology Research
Volume: 16
Issue: 5
Start Page: 217
End Page: 224
Abstract: Human HOX genes consist of 39 genes and encode transcription factors that function as master developmental regulators. We hypothesized that the misexpression of HOX genes was associated with carcinogenesis and malignant progression. The expression levels of 39 HOX genes in 31 human oral squamous cell carcinoma (SCC), 11 dysplasia, and 10 normal mucosa tissues were quantified by the real-time RT-PCR method. The expression levels of 18 HOX genes in the SCC tissues were significantly higher than those in the normal mucosa tissues. The dysplasia tissues showed higher expression of HOXA2, A3, B3, and D10 than normal mucosa tissues whereas they showed lower expression of HOXA1, B7, B9, and C8 than SCC. The SCC with lymph node metastasis showed high expression of HOXC6 compared to the SCC without it. These results suggest that misexpressions of particular HOX genes are implicated in the development of oral dysplasia and SCC.
Type: article (author version)
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 浜田 淳一

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