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Aberrant Expression of HOX Genes in Oral Dysplasia and Squamous Cell Carcinoma Tissues
| Title: | Aberrant Expression of HOX Genes in Oral Dysplasia and Squamous Cell Carcinoma Tissues |
| Authors: | Hassan, Nur Mohammad Monsur Browse this author | | Hamada, Jun-ichi Browse this author | | Murai, Taichi Browse this author | | Seino, Akihusa Browse this author | | Takahashi, Yoko Browse this author | | Tada, Mitsuhiro Browse this author | | Zhang, Xiuru Browse this author | | Kashiwazaki, Haruhiko Browse this author | | Yamazaki, Yutaka Browse this author →KAKEN DB | | Inoue, Nobuo Browse this author | | Moriuchi, Tetsuya Browse this author |
| Keywords: | HOX | | Oral squamous carcinoma | | Dysplasia | | Oral mucosa | | Metastasis |
| Issue Date: | 2006 |
| Publisher: | Cognizant Communication Corporation |
| Journal Title: | Oncology Research |
| Volume: | 16 |
| Issue: | 5 |
| Start Page: | 217 |
| End Page: | 224 |
| Abstract: | Human HOX genes consist of 39 genes and encode transcription factors that function as master developmental regulators. We hypothesized that the misexpression of HOX genes was associated with carcinogenesis and malignant progression. The expression levels of 39 HOX genes in 31 human oral squamous cell carcinoma (SCC), 11 dysplasia, and 10 normal mucosa tissues were quantified by the real-time RT-PCR method. The expression levels of 18 HOX genes in the SCC tissues were significantly higher than those in the normal mucosa tissues. The dysplasia tissues showed higher expression of HOXA2, A3, B3, and D10 than normal mucosa tissues whereas they showed lower expression of HOXA1, B7, B9, and C8 than SCC. The SCC with lymph node metastasis showed high expression of HOXC6 compared to the SCC without it. These results suggest that misexpressions of particular HOX genes are implicated in the development of oral dysplasia and SCC. |
| Relation: | http://www.cognizantcommunication.com/filecabinet/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/18638 |
| Appears in Collections: | 遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 浜田 淳一
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