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Aleukemic leukemia cutis in a patient with Philadelphia chromosome-positive biphenotypic leukemia.

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Title: Aleukemic leukemia cutis in a patient with Philadelphia chromosome-positive biphenotypic leukemia.
Authors: Onozawa, Masahiro Browse this author
Hashino, Satoshi Browse this author
Kanamori, Hiroe Browse this author
Izumiyama, Koh Browse this author
Yonezumi, Masakatsu Browse this author
Chiba, Koji Browse this author
Kondo, Takeshi Browse this author
Fukuhara, Takashi Browse this author
Tanaka, Junji Browse this author
Imamura, Masahiro Browse this author
Asaka, Masahiro Browse this author
Keywords: Aleukemic leukemia cutis
Philadelphia chromosome
Biphenotypic leukemia
Issue Date: Oct-2004
Publisher: Carden Jennings Publishing Co., Ltd.
Journal Title: International Journal of Hematology
Volume: 80
Issue: 3
Start Page: 278
End Page: 280
PMID: 15540904
Abstract: Aleukemic leukemia cutis is a rare condition characterized by the invasion of leukemic blasts into the skin before their appearance in the peripheral blood. Leukemia cutis usually occurs in patients with myeloid leukemia, especially the myelomonocytic and monocytic types of acute myeloblastic leukemia. We describe the case of a 62-year-old woman with aleukemic leukemia cutis who developed Philadelphia-positive acute leukemia 1 month after skin involvement. Leukemic cells expressed both myeloid and B-cell lineage surface markers, and monoclonal rearrangement of the immunoglobulin heavy chain was detected by Southern blot analysis. This report is the first of a case of aleukemic leukemia cutis preceding Philadelphia-positive biphenotypic leukemia.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 小野澤 真弘

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