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Inhibitory Effects of 5,6,7-Trihydroxyflavones on Tyrosinase

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Title: Inhibitory Effects of 5,6,7-Trihydroxyflavones on Tyrosinase
Authors: Gao, Hong Browse this author
Nishida, Jun Browse this author
Saito, Shizuka Browse this author
Kawabata, Jun Browse this author →KAKEN DB
Keywords: Tyrosinase inhibitor
Issue Date: Jan-2007
Publisher: Molecular Diversity Preservation International (MDPI)
Journal Title: Molecules
Volume: 12
Issue: 1
Start Page: 86
End Page: 97
Abstract: Baicalein (1), 6-hydroxyapigenin (6), 6-hydroxygalangin (13) and 6-hydroxykaempferol (14), which are naturally occurring flavonoids from a set of 14 hydroxyflavones tested, exhibited high inhibitory effects on tyrosinase with respect to L-DOPA, while each of the 5,6,7-trihydroxyflavones 1, 6, 13 or 14 acted as a cofactor to monophenolase. Moreover, 6-hydroxykaempferol (14) showed the highest activity and was a competitive inhibitor of tyrosinase compared to L-DOPA. 5,6,7- Trihydroxyflavones 1, 6, 13 or 14 showed also high antioxidant activities. Hence, we conclude that the 5,6,7-trihydroxy-flavones are useful as good depigmentation agents with inhibitory effects in addition to their antioxidant properties.
Type: article
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 川端 潤

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