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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Agriculture / Faculty of Agriculture >
Peer-reviewed Journal Articles, etc >
Inhibitory Effects of 5,6,7-Trihydroxyflavones on Tyrosinase
| Title: | Inhibitory Effects of 5,6,7-Trihydroxyflavones on Tyrosinase |
| Authors: | Gao, Hong Browse this author | | Nishida, Jun Browse this author | | Saito, Shizuka Browse this author | | Kawabata, Jun Browse this author →KAKEN DB |
| Keywords: | Tyrosinase inhibitor | | flavonoids | | 5,6,7-trihydroxyflavones | | baicalein | | melanin | | depigmentation |
| Issue Date: | Jan-2007 |
| Publisher: | Molecular Diversity Preservation International (MDPI) |
| Journal Title: | Molecules |
| Volume: | 12 |
| Issue: | 1 |
| Start Page: | 86 |
| End Page: | 97 |
| Abstract: | Baicalein (1), 6-hydroxyapigenin (6), 6-hydroxygalangin (13) and 6-hydroxykaempferol (14), which are naturally occurring flavonoids from a set of 14 hydroxyflavones tested, exhibited high inhibitory effects on tyrosinase with respect to L-DOPA, while each of the 5,6,7-trihydroxyflavones 1, 6, 13 or 14 acted as a cofactor to monophenolase. Moreover, 6-hydroxykaempferol (14) showed the highest activity and was a competitive inhibitor of tyrosinase compared to L-DOPA. 5,6,7- Trihydroxyflavones 1, 6, 13 or 14 showed also high antioxidant activities. Hence, we conclude that the 5,6,7-trihydroxy-flavones are useful as good depigmentation agents with inhibitory effects in addition to their antioxidant properties. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/18875 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 川端 潤
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