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Eradication of Helicobacter pylori for primary gastric cancer and secondary gastric cancer after endoscopic mucosal resection.

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Title: Eradication of Helicobacter pylori for primary gastric cancer and secondary gastric cancer after endoscopic mucosal resection.
Authors: Kato, Mototsugu Browse this author →KAKEN DB
Asaka, Masahiro Browse this author →KAKEN DB
Ono, Shouko Browse this author
Nakagawa, Manabu Browse this author
Nakagawa, Souichi Browse this author
Shimizu, Yuichi Browse this author →KAKEN DB
Chuma, Makoto Browse this author →KAKEN DB
Kawakami, Hiroshi Browse this author →KAKEN DB
Komatsu, Yoshito Browse this author →KAKEN DB
Hige, Shuhei Browse this author →KAKEN DB
Takeda, Hiroshi Browse this author →KAKEN DB
Keywords: Helicobacter pylori
gastric cancer
Issue Date: Jan-2007
Publisher: Springer
Journal Title: Journal of Gastroenterology
Volume: 42
Issue: s17
Start Page: 16
End Page: 20
Publisher DOI: 10.1007/s00535-006-1928-5
PMID: 17238020
Abstract: Because most gastric cancers develop from a background of Helicobacter pylori-infected gastric mucosa, H. pylori plays an important role in gastric carcinogenesis. Therefore, eradication of H. pylori may inhibit the incidence of gastric cancers. In experimental studies, H. pylori eradication has proved to act as a prophylaxis against gastric cancer. However, the results of recent randomized controlled studies are absolutely contradictory. In Japan, mucosal gastric cancer is usually resected by endoscopic treatment. As only a small part of the gastric mucosa is resected, secondary gastric cancer after endoscopic resection of the primary gastric cancer often develops at another site in the stomach. A nonrandomized Japanese study involving 132 early gastric cancer patients reported that eradication of H. pylori after endoscopic resection tended to reduce the development of secondary gastric cancer. Also, a retrospective multicenter survey indicated that the incidence rate of secondary gastric cancer in H. pylori-eradicated patients was about one-third that among patients in the noneradication group. We conducted a large-scale multicenter randomized trial to confirm the effect of H. pylori eradication on secondary and residual gastric cancer after endoscopic resection. This study was begun in 2003 and is ongoing at present. Diagnosis of a new carcinoma at another site of the stomach is defined as the primary end point, and recurrence of tumors at the resection site as a secondary end point. A total of 542 subjects have been enrolled in the study. This study will have the statistical power to demonstrate whether H. pylori eradication decreases the incidence and recurrence of gastric cancer.
Rights: The original publication is available at
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加藤 元嗣

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