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Protection of vincristine-induced neuropathy by WldS expression and the independence of the activity of Nmnat1

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Title: Protection of vincristine-induced neuropathy by WldS expression and the independence of the activity of Nmnat1
Authors: Watanabe, Masashi Browse this author
Tsukiyama, Tadasuke Browse this author
Hatakeyama, Shigetsugu Browse this author →KAKEN DB
Keywords: WldS
Wallerian degeneration
Issue Date: 16-Jan-2007
Publisher: Elsevier
Journal Title: Neuroscience Letters
Volume: 411
Issue: 3
Start Page: 228
End Page: 232
Publisher DOI: 10.1016/j.neulet.2006.09.068
PMID: 17113230
Abstract: The slow Wallerian degeneration protein (WldS), a fusion protein containing amino-terminal E4B and full-length nicotinamide mononucleotide adenylyltransferase 1 (Nmnat1), delays axon degeneration caused by physical damages, toxins and genetic mutations which result in patients being diagnosed with neurodegenerative diseases. It is still controversial whether the suppression of axonal degeneration by WldS is due to Nmnat1 or other portion. We generated WldS or Nmnat1-overexpressing Neuro2A cell lines, in which neuronal differentiation including neurite elongation can be induced by retinoic acid. The overexpression of WldS delayed the neurite degeneration by vincristine, whereas that of Nmnat1 did not delay it much. Taken together, Nmnat1 is considerably weaker than WldS for protection from toxic injury in vitro, suggesting that amino-terminal region of WldS is likely to be more significant for protection from axonal degeneration.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 畠山 鎮次

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