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The role of osteopontin in tendon tissue remodeling after denervation-induced mechanical stress deprivation

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Title: The role of osteopontin in tendon tissue remodeling after denervation-induced mechanical stress deprivation
Authors: Mori, Noriaki Browse this author
Majima, Tokifumi Browse this author
Iwasaki, Norimasa Browse this author →KAKEN DB
Kon, Shigeyuki Browse this author
Miyakawa, Kiyoshi Browse this author
Kimura, Chiemi Browse this author
Tanaka, Kunio Browse this author
Denhardt, David T. Browse this author
Rittling, Susan Browse this author
Minamia, Akio Browse this author →KAKEN DB
Uede, Toshimitsu Browse this author →KAKEN DB
Keywords: Osteopontin
Tendon remodeling
Mechanical stress deprivation
Matrix metalloproteinase-13
Issue Date: Jan-2007
Journal Title: Matrix Biology
Volume: 26
Issue: 1
Start Page: 42
End Page: 53
Publisher DOI: 10.1016/j.matbio.2006.09.002
PMID: 17055235
Abstract: It has been shown that musculoskeletal tissues undergo dynamic tissue remodeling by a process that is quite sensitive to the mechanical environment. However, the detailed molecular mechanism underlying this process remains unclear. We demonstrate here that after denervation-induced mechanical stress deprivation, tendons undergo dynamic tissue remodeling as evidenced by a significant reduction of the collagen fibril diameter. Importantly, the transient up-regulation of osteopontin (OPN) expression was characteristic during the early phase of tendon tissue remodeling. Following this dynamic change of OPN expression, matrix metalloproteinase (MMP)-13 expression was induced, which presumably accounts for the morphological changes of tendon by degrading tendon collagen fibrils. The modulation of MMP-13 expression by OPN was specific, since the expression of MMP-2, which is also known to be involved in tissue remodeling, did not alter in the tendons under the absence or presence of OPN. We also demonstrate that the modulation of MMP-13 expression by OPN is due to the signaling through cell surface receptors for OPN. Thus, we conclude that OPN plays a crucial role in conveying the effect of denervation-induced mechanical stress deprivation to the tendon fibroblasts to degrade the extracellular matrices by regulating MMP-13 expression in tendon fibroblasts.
Type: article (author version)
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 上出 利光

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