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Expression of erythropoietin receptor in human Merkel cell carcinoma of the eyelid

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Title: Expression of erythropoietin receptor in human Merkel cell carcinoma of the eyelid
Authors: Kase, Satoru Browse this author →KAKEN DB
Yoshida, Kazuhiko Browse this author →KAKEN DB
Osaki, Mitsuhiko Browse this author
Adachi, Hironobu Browse this author
Ito, Hisao Browse this author
Ohno, Shigeaki Browse this author →KAKEN DB
Keywords: merkel cell carcinoma
erythropoietin receptor
Issue Date: 2006
Publisher: International Institute of Anticancer Research
Journal Title: Anticancer Research
Volume: 26
Issue: 6B
Start Page: 4535
End Page: 4537
PMID: 17201175
Abstract: Background: Merkel cell carcinoma (MCC) of the eyelid is a rare malignant solid tumor of the elderly, which demonstrates a large, firm, reddish nodule mimicking an angiomatous lesion. The expression of erythropoietin (Epo) and Epo receptor (EpoR), as well as vascular endothelial growth factor (VEGF), VEGF receptor (VEGFR) and basic fibroblast growth factor (bFGF) were examined in human MCC tissues. Materials and Methods: Three patients diagnosed with MCC of the eyelid underwent surgical excision. Isolated tissues were fixed by 4% paraformaldehyde and then were examined using immunohistochemistry. Results: The carcinoma cells consisted of irregular tumor nests with linear stroma and showed hypercellularity indicated by small round nuclei with several mitoses. While immunoreactivity of Epo was undetectable, an increased expression of EpoR was noted in the carcinoma cells. Cytoplasmic immunoreactivity for EpoR was detected in a variety of carcinoma cells, including mitotic cells. VEGF, VEGFR, and bFGF, other angiogenic factors were not expressed in the MCC tissues. Conclusion: EpoR was highly expressed in MCC of the eyelid, suggesting that the Epo-EpoR pathway plays an important role in the formation of MCC.
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加瀬 諭

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