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Volume 17, Number 4 >

IN VITRO TRANSFORMATION OF HAMSTER CELLS BY INFECTIOUS CANINE HEPATITIS VIRUS

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.17.4.128

Title: IN VITRO TRANSFORMATION OF HAMSTER CELLS BY INFECTIOUS CANINE HEPATITIS VIRUS
Authors: KINJO, Toshio Browse this author
NISHI, Takeshi Browse this author
YANAGAWA, Ryo Browse this author
Issue Date: Dec-1969
Publisher: The Graduate School of Veterinary Medicine
Journal Title: Japanese Journal of Veterinary Research
Volume: 17
Issue: 4
Start Page: 128
End Page: 135
Abstract: Hamster cells were transformed by 9 of 11 strains of ICHV. Transformed cells formed foci of multilayered growth in the monolayer cultures. The foci appeared from 37 to 60 days after inoculation. The transformed cells were found to contain ICHV T antigen by indirect FA test. The rate of transformation was low. Tumorigenicity of the transformed cells for hamsters was low, confirmed only in 4 out of 40 animals inoculated. However, when the transformed cells were inoculated into hamsters after subcultivation, the development of the tumor was greatly increased. The tumors were confirmed specific for ICHV. From the data presented, it is shown that ICHV is capable of inducing in vitro transformation of hamster cells.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/1939
Appears in Collections:Japanese Journal of Veterinary Research > Volume 17, Number 4

Submitter: 獣医学部図書室

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