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A comparative epidemiological study of hantavirus infection in Japan and Far East Russia

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.54.4.145

Title: A comparative epidemiological study of hantavirus infection in Japan and Far East Russia
Authors: Kariwa, Hiroaki Browse this author →KAKEN DB
Lokugamage, Kumari Browse this author
Lokugamage, Nandadeva Browse this author
Miyamoto, Hironobu Browse this author
Yoshii, Kentaro Browse this author →KAKEN DB
Nakauchi, Mina Browse this author
Yoshimatsu, Kumiko Browse this author
Arikawa, Jiro Browse this author →KAKEN DB
Ivanov, Leonid I. Browse this author
Iwasaki, Takuya Browse this author
Takashima, Ikuo Browse this author
Keywords: Hantavirus
rodent
epidemiology
epizootiology
zoonosis
Issue Date: 28-Feb-2007
Publisher: The Graduate School of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 54
Issue: 4
Start Page: 145
End Page: 161
Abstract: Hantaviruses are causative agents of some severe human illnesses, including hemorrhagic fever with renal syndrome(HFRS)and hantavirus pulmonary syndrome(HPS).The viruses are maintained by rodent hosts, and humans acquire infection by inhaling virus-contaminated excreta from infected animals. To examine the epidemiology of hantavirus infections in Japan and Far East Russia, we conducted epidemiological surveys in these regions. In Japan, anti-hantavirus antibodies were found in four rodent species, Clethrionomys rufocanus, Rattus norvegicus, R. rattus, and Apodemus speciosus. Although no new HFRS cases have been officially reported over the past 20years in Japan, one member of the Japan Ground Self-Defense Force did test positive for hantavirus antibody. Repeated surveys in Far East Russia have revealed that two distinct hantavirus types cause severe HFRS in this region. Hantavirus sequences identified from A. peninsulae, fetal HFRS cases in Vladivostok, and Amur virus are highly similar to each other(>92% identity), but they are less similar(~84% identity)to the prototypical Hantaan virus, which is carried by A. agrarius. Phylogenetic analysis also indicates that Amur and A. peninsulae-associated viruses are distinct from Hantaan virus, suggesting that A. peninsulae is the reservoir animal for Amur virus, which causes severe HFRS. From HFRS patients in the Khabarovsk region, we identified viruses with nucleotide sequences that are more similar to Far East virus(>96%identity)than to the Hantaan(88‐89%identity)or Amur (81‐83%identity)viruses. Phylogenetic analysis also indicates that the viruses from Khabarovsk HFRS patients are closely related to the Far East virus, and distinct from Amur virus.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/20014
Appears in Collections:Japanese Journal of Veterinary Research > Volume 54, Number 4

Submitter: 獣医学部図書室

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