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Morphological and functional analyses of adult onset vitelliform macular dystrophy.

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Title: Morphological and functional analyses of adult onset vitelliform macular dystrophy.
Authors: Saito, W. Browse this author
Yamamoto, S. Browse this author
Hayashi, M. Browse this author
Ogata, K. Browse this author
Keywords: adult onset vitelliform macular dystrophy
optical coherence tomography
scanning laser ophthalmoscope
Issue Date: Jun-2003
Publisher: BMJ Publishing Group
Journal Title: British Journal of Ophthalmology
Volume: 87
Issue: 6
Start Page: 758
End Page: 762
Publisher DOI: 10.1136/bjo.87.6.758
PMID: 12770976
Abstract: Aim: To evaluate the morphology and visual function of the macula in eyes with adult onset vitelliform macular dystrophy (AVMD). Methods: 12 eyes of six patients with AVMD were examined by ophthalmoscopy, scanning laser ophthalmoscopy (SLO), optical coherence tomography (OCT), and multifocal electroretinography (mfERGs). The macular lesions were bilateral in all patients and varied from the typical vitelliform (five eyes), faded vitelliform changes with retinal pigment epithelium (RPE) atrophy (five eyes), and a normal fovea associated with small flecks around the macula (two eyes). Results: SLO demonstrated small abnormal bright spots in the deep retina throughout the posterior retina in all cases. OCT showed a highly reflective fusiform thickened layer at the level of the RPE and choriocapillaris in patients with a submacular yellow vitelliform lesion. A well circumscribed, optically clear space was observed beneath the retinal layer in the macular lesions with RPE atrophy. The mfERGs were significantly reduced not only in the macular area but also in the outermost ring (20–30°) of the mfERGs. Conclusions: The submacular materials that accumulate within the RPE or subepithelial layers reported in previous histopathological studies of vitelliform lesions can be detected by OCT. In the macular lesions with RPE atrophy, the material may have disappeared leaving a subretinal or subepithelial optical clear space. These SLO and mfERG observations suggest that the morphological and functional abnormalities may not be localised just in the macular area but may be present throughout the posterior pole in eyes with AVMD.
Conffering University: 東邦大学
Degree Level: 博士
Degree Discipline: 医学
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 齋藤 航

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