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Morphological and functional analyses of adult onset vitelliform macular dystrophy.

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タイトル: Morphological and functional analyses of adult onset vitelliform macular dystrophy.
著者: Saito, W. 著作を一覧する
Yamamoto, S. 著作を一覧する
Hayashi, M. 著作を一覧する
Ogata, K. 著作を一覧する
キーワード: adult onset vitelliform macular dystrophy
optical coherence tomography
scanning laser ophthalmoscope
発行日: 2003年 6月
出版者: BMJ Publishing Group
誌名: British Journal of Ophthalmology
巻: 87
号: 6
開始ページ: 758
終了ページ: 762
出版社 DOI: 10.1136/bjo.87.6.758
抄録: Aim: To evaluate the morphology and visual function of the macula in eyes with adult onset vitelliform macular dystrophy (AVMD). Methods: 12 eyes of six patients with AVMD were examined by ophthalmoscopy, scanning laser ophthalmoscopy (SLO), optical coherence tomography (OCT), and multifocal electroretinography (mfERGs). The macular lesions were bilateral in all patients and varied from the typical vitelliform (five eyes), faded vitelliform changes with retinal pigment epithelium (RPE) atrophy (five eyes), and a normal fovea associated with small flecks around the macula (two eyes). Results: SLO demonstrated small abnormal bright spots in the deep retina throughout the posterior retina in all cases. OCT showed a highly reflective fusiform thickened layer at the level of the RPE and choriocapillaris in patients with a submacular yellow vitelliform lesion. A well circumscribed, optically clear space was observed beneath the retinal layer in the macular lesions with RPE atrophy. The mfERGs were significantly reduced not only in the macular area but also in the outermost ring (20–30°) of the mfERGs. Conclusions: The submacular materials that accumulate within the RPE or subepithelial layers reported in previous histopathological studies of vitelliform lesions can be detected by OCT. In the macular lesions with RPE atrophy, the material may have disappeared leaving a subretinal or subepithelial optical clear space. These SLO and mfERG observations suggest that the morphological and functional abnormalities may not be localised just in the macular area but may be present throughout the posterior pole in eyes with AVMD.
学位授与機関: 東邦大学
取得学位の種別: 博士
取得学位の分野: 医学
資料タイプ: article
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 齋藤 航


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