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Positive correlation between vitreous levels of advanced glycation end products and vascular endothelial growth factor in patients with diabetic retinopathy sufficiently treated with photocoagulation

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タイトル: Positive correlation between vitreous levels of advanced glycation end products and vascular endothelial growth factor in patients with diabetic retinopathy sufficiently treated with photocoagulation
著者: Yokoi, Masahiko 著作を一覧する
Yamagishi, Sho-ichi 著作を一覧する
Takeuchi, Masayoshi 著作を一覧する
Matsui, Takanori 著作を一覧する
Yoshida, Yumiko 著作を一覧する
Ohgami, Kazuhiro 著作を一覧する
Amano-Okamoto, Tamami 著作を一覧する
Ohno, Shigeaki 著作を一覧する
発行日: 2007年 3月
出版者: BMJ Publishing Group
誌名: British Journal of Ophthalmology
巻: 91
号: 3
開始ページ: 397
終了ページ: 398
出版社 DOI: 10.1136/bjo.2006.100198
抄録: We investigated whether vitreous levels of advanced glycation end products (AGEs) were positively correlated with vascular endothelial growth factor (VEGF) in patients with diabetic retinopathy patients sufficiently treated with retinal photocoagulation. Vitreous AGE and VEGF levels were significantly higher in patients with diabetes than in controls. Positive correlation between AGE and VEGF was found in patients with diabetic retinopathy sufficiently treated with retinal photocoagulation (r = 0.44, p<0.05), but not in those who were insufficiently treated (r = 0.26, p = 0.18). The present observations suggest that AGE may induce VEGF expression in an ischaemia-independent mechanism. AGE could be one of the important determinants of VEGF in diabetic retinopathy without obvious ischaemic regions.
Relation (URI): http://www.bmj.com/
資料タイプ: article
URI: http://hdl.handle.net/2115/20277
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 大野 重昭

 

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