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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Positive correlation between vitreous levels of advanced glycation end products and vascular endothelial growth factor in patients with diabetic retinopathy sufficiently treated with photocoagulation
| Title: | Positive correlation between vitreous levels of advanced glycation end products and vascular endothelial growth factor in patients with diabetic retinopathy sufficiently treated with photocoagulation |
| Authors: | Yokoi, Masahiko Browse this author | | Yamagishi, Sho-ichi Browse this author | | Takeuchi, Masayoshi Browse this author | | Matsui, Takanori Browse this author | | Yoshida, Yumiko Browse this author | | Ohgami, Kazuhiro Browse this author | | Amano-Okamoto, Tamami Browse this author | | Ohno, Shigeaki Browse this author |
| Issue Date: | Mar-2007 |
| Publisher: | BMJ Publishing Group |
| Journal Title: | British Journal of Ophthalmology |
| Volume: | 91 |
| Issue: | 3 |
| Start Page: | 397 |
| End Page: | 398 |
| Publisher DOI: | 10.1136/bjo.2006.100198 |
| PMID: | 17322470 |
| Abstract: | We investigated whether vitreous levels of advanced glycation end products (AGEs) were positively correlated with vascular endothelial growth factor (VEGF) in patients with diabetic retinopathy patients sufficiently treated with retinal photocoagulation. Vitreous AGE and VEGF levels were significantly higher in patients with diabetes than in controls. Positive correlation between AGE and VEGF was found in patients with diabetic retinopathy sufficiently treated with retinal photocoagulation (r = 0.44, p<0.05), but not in those who were insufficiently treated (r = 0.26, p = 0.18). The present observations suggest that AGE may induce VEGF expression in an ischaemia-independent mechanism. AGE could be one of the important determinants of VEGF in diabetic retinopathy without obvious ischaemic regions. |
| Relation: | http://www.bmj.com/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/20277 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 大野 重昭
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