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Volume 24, Number 3-4 >

EFFECT OF CYCLOPHOSPHAMIDE ON THE THYMUS AND THE BURSA OF FABRICIUS IN CHICKENS

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.24.3-4.87

Title: EFFECT OF CYCLOPHOSPHAMIDE ON THE THYMUS AND THE BURSA OF FABRICIUS IN CHICKENS
Authors: HIRAGA, Takeo Browse this author
SUGIMURA, Makoto Browse this author
KUDO, Norio Browse this author
Issue Date: Oct-1976
Publisher: The Graduate School of Veterinary Medicine
Journal Title: Japanese Journal of Veterinary Research
Volume: 24
Issue: 3-4
Start Page: 87
End Page: 98
Abstract: The effect of cyclophosphamide (Cy) on the thymus and the bursa of Fabricius in chickens, aged one day to 7 weeks, was examined morphologically. Chickens, which were daily injected i.m. with 6 mg Cy 1,2,or 3 times from the hatching day, were compared with saline control chickens. The relative weights of both the thymus and the bursa decreased abruptly just after the injection of Cy. The weight of the thymus had an involutional bottom at the age of 4〜5 days, and thereafter recovered to the normal level at age 3 weeks, while that of the bursa never returned to the control level until age 7 weeks. The histological changes in the thymus appeared to be greater in the cortex than in the medulla. A degeneration of lymphocytes, an increase of macrophages, hypertrophy of the reticular cells, and a disappearance of mitotic cells were observed in the cortex during early involution. Recovery began as soon as the large lymphocytes appeared in the cortex, and the histological structures of the thymuses in the Cy-treated birds recovered completely at age 3 weeks. The effect of Cy in the bursa was similar to that in the thymus, but these changes were seen earlier than they were in the thymus. Restoration of the lymphoid follicles was observed from 5 to 10 days of age mainly in the groups treated with a smaller quantity of Cy. In the chickens treated with 18 mg Cy, however, only a few restorative follicles were found.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/2084
Appears in Collections:Japanese Journal of Veterinary Research > Volume 24, Number 3-4

Submitter: 獣医学部図書室

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