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Volume 25, Number 3-4 >

PATHOLOGICAL STUDIES OF MAREK'S DISEASE III ELECTRON MICROSCOPIC OBSERVATION ON DEMYELINATION OF THE PERIPHERAL NERVES

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.25.3-4.59

Title: PATHOLOGICAL STUDIES OF MAREK'S DISEASE III ELECTRON MICROSCOPIC OBSERVATION ON DEMYELINATION OF THE PERIPHERAL NERVES
Authors: FUJIMOTO, Yutaka Browse this author
OKADA, Kosuke Browse this author
Issue Date: Oct-1977
Publisher: The Graduate School of Veterinary Medicine
Journal Title: Japanese Journal of Veterinary Research
Volume: 25
Issue: 3-4
Start Page: 59
End Page: 70
Abstract: Degenerative changes of the peripheral nerves in Marek's diseases (MD) were investigated under light and electron microscopy. Three categories of demyelination were classified according to the characteristics of the lesions. Category I was considered as primary demyelination, and it was similar to experimental allergic neuritis. No morphological destruction was seen in the myelin sheath until the mononuclear cells made contact with the myelin within the neurolemma. The attacking mononuclear cells (macrophages) stripped the Schwann cell cytoplasm off the myelin sheath. Category II was considered as Wallerian-like degeneration. Category III was considered as a "hydration" of myelin sheaths due to edema. Myelinolysis, caused by a uniform separation of myelin lamellae in the region of the sub-perineurial edema, was observed independently of MD. The regenerative process, particularly remyelination, was seen in each category. It was suggested that primary demyelination of Category I was the most important phenomena in the pathogenesis of MD nerve lesions.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/2120
Appears in Collections:Japanese Journal of Veterinary Research > Volume 25, Number 3-4

Submitter: 獣医学部図書室

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