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Volume 26, Number 3-4 >

ANTI-TUMOR IMMUNITY AGAINST MAREK'S DISEASE-DERIVED LYMPHOBLASTOID CELL LINE (MSB-1)

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.26.3-4.57

Title: ANTI-TUMOR IMMUNITY AGAINST MAREK'S DISEASE-DERIVED LYMPHOBLASTOID CELL LINE (MSB-1)
Authors: SUGIMOTO, Chihiro Browse this author
KODAMA, Hiroshi Browse this author
MIKAMI, Takeshi Browse this author
Issue Date: Oct-1978
Publisher: The Graduate School of Veterinary Medicine
Journal Title: Japanese Journal of Veterinary Research
Volume: 26
Issue: 3-4
Start Page: 57
End Page: 67
Abstract: Cytotoxic effects of peripheral blood lymphocytes (PBL) and immune sera from chickens infected with Marek's disease virus (MDV) or vaccinated with herpesvirus of turkey (HVT) against Marek's disease lymphoblastoid cell line (MSB-1) cells were studied. Cellular immunity was assayed using lymphocytes collected 60 to 180 days postinfection. Lymphocyte cytotoxicity tests revealed that the PBL of MDV infected chickens had cytotoxic effects against MSB-1 but those of HVT-vaccinated chickens did not. In complement-dependent antibody cytotoxicity (CDAC) and antibody-dependent cell-mediated cytotoxicity (ADCC) tests, no cytotoxic activity of sera from MDV- or HVT-infected chickens was demonstrated. However, after the sera of chickens immunized with inactivated MSB-1 cells were extensively absorbed with chicken red blood cells, these sera had cytotoxic effects against MSB-1 cells in CDAC and ADCC tests.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/2150
Appears in Collections:Japanese Journal of Veterinary Research > Volume 26, Number 3-4

Submitter: 獣医学部図書室

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