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Volume 28, Number 1-2 >

ISOLATION OF ANTIGENIC MUTANTS OF TYPE 1 POLIOVIRUS : GROWING THE VIRUS IN THE PRESENCE OF HOMOLOGOUS ANTISERUM

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この文献には次のDOIがあります:http://doi.org/10.14943/jjvr.28.1-2.19

タイトル: ISOLATION OF ANTIGENIC MUTANTS OF TYPE 1 POLIOVIRUS : GROWING THE VIRUS IN THE PRESENCE OF HOMOLOGOUS ANTISERUM
著者: HASHIMOTO, Nobuo 著作を一覧する
発行日: 1980年 5月31日
出版者: The Graduate School of Veterinary Medicine
誌名: Japanese Journal of Veterinary Research
巻: 28
号: 1-2
開始ページ: 19
終了ページ: 30
抄録: The antigenic mutants, which were significantly different intra-typically from the parental Mahoney-1709 type 1 poliovirus, were repeatedly isolated after a number of serial virus passages in the presence of homologous anti-Mahoney sera. The levels of the antigenic variation of those mutant viruses varied, depending on the individual antiserum employed for mutant selection and the passage numbers with same antiserum. The susceptibility to certain serum inhibitors of the antigenic mutants varied according to the antisera AMS_3 and AMS_4 employed for the mutant selection, but was not dependent on the passage numbers using the same antiserum. There is evidence that the antisera contained antibodies indistinguishable from the serum inhibitors in the specific antiviral activity, and that the production of these antibodies varied with the results of individual variations in the animals receiving the antigenic stimulus.
資料タイプ: bulletin
URI: http://hdl.handle.net/2115/2183
出現コレクション:Volume 28, Number 1-2

提供者: 獣医学部図書室

 

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