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Volume 28, Number 1-2 >

ISOLATION OF ANTIGENIC MUTANTS OF TYPE 1 POLIOVIRUS : GROWING THE VIRUS IN THE PRESENCE OF HOMOLOGOUS ANTISERUM

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.28.1-2.19

Title: ISOLATION OF ANTIGENIC MUTANTS OF TYPE 1 POLIOVIRUS : GROWING THE VIRUS IN THE PRESENCE OF HOMOLOGOUS ANTISERUM
Authors: HASHIMOTO, Nobuo Browse this author
Issue Date: 31-May-1980
Publisher: The Graduate School of Veterinary Medicine
Journal Title: Japanese Journal of Veterinary Research
Volume: 28
Issue: 1-2
Start Page: 19
End Page: 30
Abstract: The antigenic mutants, which were significantly different intra-typically from the parental Mahoney-1709 type 1 poliovirus, were repeatedly isolated after a number of serial virus passages in the presence of homologous anti-Mahoney sera. The levels of the antigenic variation of those mutant viruses varied, depending on the individual antiserum employed for mutant selection and the passage numbers with same antiserum. The susceptibility to certain serum inhibitors of the antigenic mutants varied according to the antisera AMS_3 and AMS_4 employed for the mutant selection, but was not dependent on the passage numbers using the same antiserum. There is evidence that the antisera contained antibodies indistinguishable from the serum inhibitors in the specific antiviral activity, and that the production of these antibodies varied with the results of individual variations in the animals receiving the antigenic stimulus.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/2183
Appears in Collections:Japanese Journal of Veterinary Research > Volume 28, Number 1-2

Submitter: 獣医学部図書室

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