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Volume 28, Number 4 >

EFFECT OF BURSECTOMY ON THE PATHOGENESIS OF MAREK'S DISEASE

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この文献には次のDOIがあります:http://doi.org/10.14943/jjvr.28.4.137

タイトル: EFFECT OF BURSECTOMY ON THE PATHOGENESIS OF MAREK'S DISEASE
著者: ISOGAI, Hiroshi 著作を一覧する
FUJIMOTO, Yutaka 著作を一覧する
OKADA, Kosuke 著作を一覧する
ICHIJO, Kazuyuki 著作を一覧する
発行日: 1981年 1月31日
出版者: The Graduate School of Veterinary Medicine
誌名: Japanese Journal of Veterinary Research
巻: 28
号: 4
開始ページ: 137
終了ページ: 148
抄録: The effect of bursectomy on the development of Marek's disease (MD) in chickens was studied histopathologically in two separate experiments in which 2 groups of untreated and bursectomized chickens were used. In experiment I, 16 untreated and 25 bursectomized chickens were examined at 3,5,7,9 and 12 weeks old, and in experiment II, 55 chickens, including 28 bursectomized ones, were inoculated with Marek's disease virus (MDV) at 2 weeks old. The neonatal bursectomized chickens in experiment I showed the following morphological and functional changes in comparison with the untreated chickens. 1 Histopathologically, there was a severe deplation of lymphocytes in the bursa-dependent areas and aplasia of the germinal centers in the spleen. 2 There was a lack of antibody synthesis against Salmonella pullorum. 3 There was no reduction of phytohemagglutinin (PHA) skin reaction. In experiment II, the chickens were examined at 1,3,5,7 and 10 weeks after inoculation with MDV ; the following changes were observed. 1 There were no initial cytolytic lesions in the lymphoid tissues of the bursectomized chickens. 2 Both the bursectomized and the untreated chickens showed a high and almost identical frequency of MD tumor development in various organs and tissues. In the lesions of these findings, we concluded that the function of the bursa of Fabricius is not essential for the tumorigenesis of MD.
資料タイプ: bulletin
URI: http://hdl.handle.net/2115/2207
出現コレクション:Volume 28, Number 4

 

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