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Volume 28, Number 4 >

EFFECT OF BURSECTOMY ON THE PATHOGENESIS OF MAREK'S DISEASE

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.28.4.137

Title: EFFECT OF BURSECTOMY ON THE PATHOGENESIS OF MAREK'S DISEASE
Authors: ISOGAI, Hiroshi Browse this author
FUJIMOTO, Yutaka Browse this author
OKADA, Kosuke Browse this author
ICHIJO, Kazuyuki Browse this author
Issue Date: 31-Jan-1981
Publisher: The Graduate School of Veterinary Medicine
Journal Title: Japanese Journal of Veterinary Research
Volume: 28
Issue: 4
Start Page: 137
End Page: 148
Abstract: The effect of bursectomy on the development of Marek's disease (MD) in chickens was studied histopathologically in two separate experiments in which 2 groups of untreated and bursectomized chickens were used. In experiment I, 16 untreated and 25 bursectomized chickens were examined at 3,5,7,9 and 12 weeks old, and in experiment II, 55 chickens, including 28 bursectomized ones, were inoculated with Marek's disease virus (MDV) at 2 weeks old. The neonatal bursectomized chickens in experiment I showed the following morphological and functional changes in comparison with the untreated chickens. 1 Histopathologically, there was a severe deplation of lymphocytes in the bursa-dependent areas and aplasia of the germinal centers in the spleen. 2 There was a lack of antibody synthesis against Salmonella pullorum. 3 There was no reduction of phytohemagglutinin (PHA) skin reaction. In experiment II, the chickens were examined at 1,3,5,7 and 10 weeks after inoculation with MDV ; the following changes were observed. 1 There were no initial cytolytic lesions in the lymphoid tissues of the bursectomized chickens. 2 Both the bursectomized and the untreated chickens showed a high and almost identical frequency of MD tumor development in various organs and tissues. In the lesions of these findings, we concluded that the function of the bursa of Fabricius is not essential for the tumorigenesis of MD.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/2207
Appears in Collections:Japanese Journal of Veterinary Research > Volume 28, Number 4

Submitter: 獣医学部図書室

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