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The effect of antagonism of adenosine A1 receptor against ischemia and reperfusion injury of the liver

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タイトル: The effect of antagonism of adenosine A1 receptor against ischemia and reperfusion injury of the liver
著者: Magata, Shinichiro 著作を一覧する
Taniguchi, Masahiko 著作を一覧する
Suzuki, Tomomi 著作を一覧する
Shimamura, Tsuyoshi 著作を一覧する
Fukai, Moto 著作を一覧する
Furukawa, Hiroyuki 著作を一覧する
Fujita, Miri 著作を一覧する
Todo, Satoru 著作を一覧する
キーワード: liver
ischemia and reperfusion injury
adenosine A1 receptor antagonist
発行日: 2007年 5月 1日
出版者: Elsevier
誌名: Journal of Surgical Research
巻: 139
号: 1
開始ページ: 7
終了ページ: 14
出版社 DOI: 10.1016/j.jss.2006.09.021
抄録: Background: Adenosine is known to exert protective roles in hepatic ischemia and reperfusion injury, while all adenosine receptors do not play the cytoprotective roles. We have tested our hypothesis that blockage of adenosine binding to A1 receptor by its antagonist, KW3902 [8-(noradamantan-3-yl)-1,3-dipropylxanthine] attenuates hepatic ischemia-reperfusion injury. Methods: Adult female beagle dogs underwent a 2 h total hepatic vascular exclusion (THVE) with a venovenous bypass. Nontreated animals that underwent THVE with a venovenous bypass alone were used as the control (Group CT, n = 6). KW3902 was given to the animals by continuous intraportal infusion for 60 min before ischemia at a dose of 1μg/kg/min (Group KW, n = 6). Two wk survival, hemodynamics, hepatic tissue blood flow (HTBF), liver function, energy metabolism, cAMP concentration, and histopathological findings were studied. Results: Two wk animal survival was significantly improved in group KW compared with that in group CT (group CT: 16.7% versus group KW: 83.3%). HTBF, liver function, and hepatic adenine nucleotide concentration were remarkably better in group KW than group CT. In addition, cAMP concentration in group KW was maintained significantly higher than group CT. Histopathological examination revealed preservation of hepatic architecture and suppression of neutrophil infiltration into hepatic tissue in group KW. Conclusion: Administration of adenosine A1 receptor antagonist before ischemia attenuates hepatic ischemia-reperfusion injury. To elicit the beneficial effect of adenosine against ischemia and reperfusion injury of the liver, it is important to oppose adenosine A1 receptor activation.
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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