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Japanese Journal of Veterinary Research >
Volume 31, Number 2 >

LYMPHOCYTE TRANSFORMATION OF PERIPHERAL BLOOD LYMPHOCYTES AND PLAQUE FORMING CELLS OF THE SPLEEN AND THE MESENTERIC LYMPH NODE IN SUCKLING PIGLETS WITH AND WITHOUT IMMUNOPOTENTIATORS

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この文献には次のDOIがあります:http://doi.org/10.14943/jjvr.31.2.53

タイトル: LYMPHOCYTE TRANSFORMATION OF PERIPHERAL BLOOD LYMPHOCYTES AND PLAQUE FORMING CELLS OF THE SPLEEN AND THE MESENTERIC LYMPH NODE IN SUCKLING PIGLETS WITH AND WITHOUT IMMUNOPOTENTIATORS
著者: NAMIOKA, Shigeo 著作を一覧する
OHSUGI, Takeo 著作を一覧する
FUJIMOTO, Toshiro 著作を一覧する
MAEDE, Yoshimitsu 著作を一覧する
キーワード: suckling piglet
lymphocyte transformation
plaque forming cell
immunopotentiator
immunodeficiency
発行日: 1983年 5月13日
出版者: The Graduate School of Veterinary Medicine
誌名: Japanese Journal of Veterinary Research
巻: 31
号: 2
開始ページ: 53
終了ページ: 64
抄録: Lymphocyte transformation with mitogen, phytohemagglitinin (PHA) and concanavalin A (conA) was tested in peripheral blood lymphocytes from suckling piglets aged 1,2,3,4 and 5 weeks old respectively. A study was also made to observe plaque forming cells with sheep red blood cells (SRBC) in the spleen and nucleated cells of the mesenteric lymph nodes (MLN) of piglets aged 2,3 and 4 weeks respectively. Reratively high levels of lymphocyte responses were seen in the 1 week-old piglets. Differences of stimulation indexes (SI) of lymphocyte responses of the piglets were not significant in the animals aged from 1 to 5 weeks. The effect of administration of peptidoglycan and chemical composites of cultural supernates derived from Streptomyces olivaceogriseus sp. nov (FR41565) on the lymphocyte responses was investigated. The value of SI among the piglets treated with and without peptidoglycan and FR41565 was not significant. On the other hand, the count of plaque forming cells (PFC) of the splenic and MLN's cells with SRBC in the piglets aged 2 to 4 weeks was low in spite of the SRBC injections, and the count of PFC of MLN was fewer than that of the spleen of any age. The count of PFC was the highest in the piglets treated with the rapid acting immunopotentiator (FR41565) at 2 weeks of age while the highest count was seen in the piglets administered the slow acting substance (peptidoglycan) at 4 weeks of age. These results indicated that differentiation of B lymphocyte in suckling age piglets seems to be restrained by a certain suppressive activity which leads to poor production of immunoglobulin.
資料タイプ: bulletin
URI: http://hdl.handle.net/2115/2274
出現コレクション:Volume 31, Number 2

提供者: 獣医学部図書室

 

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