HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
Japanese Journal of Veterinary Research >
Volume 32, Number 3 >

CHARACTERIZATION OF TRANSPLANTABLE SUBLINE MDCC-MSB1-CLO. 18 DERIVED FROM MDCC-MSB1

Files in This Item:
KJ00002374255.pdf509.64 kBPDFView/Open
Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.32.3.155

Title: CHARACTERIZATION OF TRANSPLANTABLE SUBLINE MDCC-MSB1-CLO. 18 DERIVED FROM MDCC-MSB1
Authors: HIGASHIHARA, Tomoko Browse this author
KUNIHIRO, Kazuaki Browse this author
YAMAKI, Tetsuya Browse this author
OKADA, Ikuo Browse this author
KODAMA, Hiroshi Browse this author
IZAWA, Hisao Browse this author
MIKAMI, Takeshi Browse this author
Keywords: MDCC-MSB1
MDCC-MSB1-Clo. 18
lymphoblastoid cell line
Marek's disease
transplantable cell line
Issue Date: 25-Jul-1984
Publisher: The Graduate School of Veterinary Medicine
Journal Title: Japanese Journal of Veterinary Research
Volume: 32
Issue: 3
Start Page: 155
End Page: 163
Abstract: MDCC-MSB1-Clo. 18 subline, derived from a Marek's disease (MD) lymphoblastoid cell line MDCC-MSB1,was highly transplantable and lethal for chickens. A dose-response relationship was observed between the number of tumor cells inoculated and the development of tumors in the recipient chickens. In addition to lymphoma formation at the site of transplantation, the recipients developed metastatic lesions in various visceral organs. Age resistance of the chickens to the tumor development was also observed. No tumor development was observed in nude mice inoculated with MDCC-MSB1-Clo. 18 cells. MD virus was isolated from duck embryo fibroblasts inoculated with MDCC-MSB1-Clo. 18 cells and also from kidney cell cultures of MDCC-MSB1-Clo. 18-inoculated chickens. MDCC-MSB1-Clo. 18 cells reacted with anti-B_E and B_K sera in the membrane immunofluorescence test. The tumor cells collected from the chickens also reacted with anti-B_E and B_K sera, while the erythrocytes from these chickens did not react with these antisera. This indicated that the tumors were originated from the inoculated cells.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/2308
Appears in Collections:Japanese Journal of Veterinary Research > Volume 32, Number 3

Submitter: 獣医学部図書室

Export metadata:

OAI-PMH ( junii2 , jpcoar )

MathJax is now OFF:


 

Feedback - Hokkaido University