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Japanese Journal of Veterinary Research >
Volume 40, Number 2-3  >

IMMUNE RESPONSE TO ECHINOCOCCUS MULTILOCULARIS INFECTION IN THE MOUSE MODEL : A REVIEW

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この文献には次のDOIがあります:http://doi.org/10.14943/jjvr.40.2-3.113

タイトル: IMMUNE RESPONSE TO ECHINOCOCCUS MULTILOCULARIS INFECTION IN THE MOUSE MODEL : A REVIEW
著者: PLAYFORD, Matthew C. 著作を一覧する
KAMIYA, Masao 著作を一覧する
キーワード: Echinococcus multilocularis
mouse
immune response
lymphocyte
cell-mediated immunity
immunosuppression
macrophage
発行日: 1992年 9月30日
出版者: The Graduate School of Veterinary Medicine
誌名: Japanese Journal of Veterinary Research
巻: 40
号: 2-3
開始ページ: 113
終了ページ: 130
抄録: Echinococcus multilocularis is a cestode helminth which, along with E. granulosus, E. oligarthus and E. vogeli is a causative agent of hydatid disease in man. In the intermediate host (including man), cysts formed by the metacestode (larval stage) develop in the internal organs, causing functional impairment which often leads to the death of the host. In this review larval E. multilocularis infection in mice, the most popular experimental intermediate host, is examined, and the immune response to the organism is described in detail. Evidence is presented which suggests that cell-mediated immunity (CMI) plays a large role in suppression of larval growth. Congenitally athymic nude mice, and mice treated to remove thymocytes had high susceptibility to infection, while mice strains assessed as having high helper T lymphocyte function showed resistance to infection. The degree of antibody response shown by the host does not correlate with the susceptibility to E. multilocularis. Infection with E. multilocularis is accompanied by immunosuppression, manifested by inhibition of effector cell chemotaxis and receptor expression, suppressor macrophage and lymphocyte activity, decline in helper T-lymphocyte activity and immune-complex deposition.
資料タイプ: bulletin
URI: http://hdl.handle.net/2115/2403
出現コレクション:Volume 40, Number 2-3

 

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