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Volume 40, Number 2-3  >

IMMUNE RESPONSE TO ECHINOCOCCUS MULTILOCULARIS INFECTION IN THE MOUSE MODEL : A REVIEW

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.40.2-3.113

Title: IMMUNE RESPONSE TO ECHINOCOCCUS MULTILOCULARIS INFECTION IN THE MOUSE MODEL : A REVIEW
Authors: PLAYFORD, Matthew C. Browse this author
KAMIYA, Masao Browse this author
Keywords: Echinococcus multilocularis
mouse
immune response
lymphocyte
cell-mediated immunity
immunosuppression
macrophage
Issue Date: 30-Sep-1992
Publisher: The Graduate School of Veterinary Medicine
Journal Title: Japanese Journal of Veterinary Research
Volume: 40
Issue: 2-3
Start Page: 113
End Page: 130
Abstract: Echinococcus multilocularis is a cestode helminth which, along with E. granulosus, E. oligarthus and E. vogeli is a causative agent of hydatid disease in man. In the intermediate host (including man), cysts formed by the metacestode (larval stage) develop in the internal organs, causing functional impairment which often leads to the death of the host. In this review larval E. multilocularis infection in mice, the most popular experimental intermediate host, is examined, and the immune response to the organism is described in detail. Evidence is presented which suggests that cell-mediated immunity (CMI) plays a large role in suppression of larval growth. Congenitally athymic nude mice, and mice treated to remove thymocytes had high susceptibility to infection, while mice strains assessed as having high helper T lymphocyte function showed resistance to infection. The degree of antibody response shown by the host does not correlate with the susceptibility to E. multilocularis. Infection with E. multilocularis is accompanied by immunosuppression, manifested by inhibition of effector cell chemotaxis and receptor expression, suppressor macrophage and lymphocyte activity, decline in helper T-lymphocyte activity and immune-complex deposition.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/2403
Appears in Collections:Japanese Journal of Veterinary Research > Volume 40, Number 2-3

Submitter: 獣医学部図書室

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