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Volume 40, Number 4 >

DISSEMINATED INTRAVASCULAR COAGULATION (DIC) IN RABBIT HAEMORRHAGIC DISEASE

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.40.4.133

Title: DISSEMINATED INTRAVASCULAR COAGULATION (DIC) IN RABBIT HAEMORRHAGIC DISEASE
Authors: UEDA, Kaoru Browse this author
PARK, Jae-Hak Browse this author
OCHIAI, Kenji Browse this author →KAKEN DB
ITAKURA, Chitoshi Browse this author
Keywords: rabbit haemorrhagic disease
DIC
blood
hepatitis
calicivirus
Issue Date: 28-Dec-1992
Publisher: The Graduate School of Veterinary Medicine
Journal Title: Japanese Journal of Veterinary Research
Volume: 40
Issue: 4
Start Page: 133
End Page: 141
Abstract: Seven rabbits experimentally infected with rabbit haemorrhagic disease virus were examined haematologically and histologically. Haematologically, activated partial thromboplastin time and prothrombin time were markedly prolonged in the terminal phase of the disease, just prior to death (all the animals died between 27 and 40 hr after inoculation with rabbit haemorrhagic disease virus). There was an increase in the titre of fibrin degradation products and a decrease in antithrombin III activity during the same interval. Acute necrotic hepatitis and disseminated intravascular coagulation (DIC) in many organs, including the lung, kidney, spleen and heart were the characteristic histopathological changes. Thus, the haematological and histological changes suggested that DIC was induced by rabbit haemorrhagic disease virus infection. Severe liver necrosis was considered to be a factor causing DIC by inducing a hypercoagulable condition in the systemic blood circulation.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/2404
Appears in Collections:Japanese Journal of Veterinary Research > Volume 40, Number 4

Submitter: 獣医学部図書室

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