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Ligand-dependent transcription of estrogen receptor α is mediated by the ubiquitin ligase EFP

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Title: Ligand-dependent transcription of estrogen receptor α is mediated by the ubiquitin ligase EFP
Authors: Nakajima, Ayako Browse this author
Maruyama, Satoru Browse this author
Bohgaki, Miyuki Browse this author
Miyajima, Naoto Browse this author
Tsukiyama, Tadasuke Browse this author
Sakuragi, Noriaki Browse this author →KAKEN DB
Hatakeyama, Shigetsugu Browse this author →KAKEN DB
Keywords: Estrogen receptor
Estrogen-responsive finger protein
Issue Date: 25-May-2007
Publisher: Elsevier Inc.
Journal Title: Biochemical and Biophysical Research Communications
Volume: 357
Issue: 1
Start Page: 245
End Page: 251
Publisher DOI: 10.1016/j.bbrc.2007.03.134
PMID: 17418098
Abstract: Estrogen-mediated ubiquitylation and subsequent degradation of the estrogen receptor α (ERα) appears to be involved in the transcriptional activity of ERα. We show that the estrogen-responsive finger protein (EFP) interacts with and ubiquitylates ERα. EFP promoted the ubiquitylation of ERα in vitro and in vivo and consequently promoted the degradation of ERα. The interaction between EFP and ERα was greatly enhanced in the presence of estrogen. The action of EFP on ERα in the presence of estrogen resulted in a robust interaction between ERα and Tip60, one of the transcriptional coactivators, leading to activation of ERα transcriptional activity. However, a dominant negative mutant of EFP lacking the RING domain prolonged the half-life of ERα and inhibited the transcription by ERα. Our results indicate that EFP functions as a cofactor for ERα-mediated transcription, thus suggesting that ERα-mediated transcription is closely linked to the ubiquitylation of ERα.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 畠山 鎮次

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