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Volume 42, Number 2 >

THE INHIBITORY EFFECTS OF MgSO_4 ON THE MULTIPLICATION AND TRANSCRIPTION OF MOUSE HEPATITIS VIRUS

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.42.2.95

Title: THE INHIBITORY EFFECTS OF MgSO_4 ON THE MULTIPLICATION AND TRANSCRIPTION OF MOUSE HEPATITIS VIRUS
Authors: MIZUTANI, Tetsuya Browse this author
HAYASHI, Masanobu Browse this author
MAEDA, Akihiko Browse this author
ISHIDA, Kozue Browse this author
WATANABE, Tomomasa Browse this author
NAMIOKA, Shigeo Browse this author
Keywords: MHV
Inhibition
viral multiplication
RNA synthesis
MgSO_4
Issue Date: 31-Aug-1994
Publisher: The Graduate School of Veterinary Medicine
Journal Title: Japanese Journal of Veterinary Research
Volume: 42
Issue: 2
Start Page: 95
End Page: 102
Abstract: The multiplication of mouse hepatitis virus (MHV) was inhibited by the treatment of infected cells with MgSO_4 at concentrations higher than 50 mM. The inhibition of viral multiplication was more effective with the treatment of cells at the early stage of infection using MgSO_4 than at the late stage. Viral adsorption to the cells was not inhibited by MgSO_4 and pretreatment of the cells with MgSO_4 did not show an inhibitory effect on the RNA synthesis of MHV. The synthesis of viral RNA was inhibited more effectively by the treatment of infected cells with MgSO_4 at 0-2 and 2-4 h postinfection (p.i.) than at 4-6 h p.i. The present study suggests that the stage at which viral multiplication is susceptible to MgSO_4 may be the early stage of viral transcription and that Mg^<2+> may be a useful tool for the analysis of the early stage of MHV infection.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/2470
Appears in Collections:Japanese Journal of Veterinary Research > Volume 42, Number 2

Submitter: 獣医学部図書室

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