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Volume 42, Number 3-4 >

THE INHIBITORY ACTION OF LEAD ON MECHANICAL RESPONSES OF THE PROVENTRICULAR SMOOTH MUSCLE IN THE CHICK

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.42.3-4.109

Title: THE INHIBITORY ACTION OF LEAD ON MECHANICAL RESPONSES OF THE PROVENTRICULAR SMOOTH MUSCLE IN THE CHICK
Authors: KUBOTA, Kazufumi Browse this author
ITO, Shigeo Browse this author
OHTA, Toshio Browse this author
NAKAZATO, Yoshikazu Browse this author
OHGA, Akira Browse this author
Keywords: Autonomic transmission
Ca^<2+> influx
chick stomach
Issue Date: 31-Jan-1995
Publisher: The Graduate School of Veterinary Medicine
Journal Title: Japanese Journal of Veterinary Research
Volume: 42
Issue: 3-4
Start Page: 109
End Page: 117
Abstract: The purpose of the present experiments was to examine the mechanism of the proventricular dilatation caused by lead in the isolated vagus nerveproventricular smooth muscle preparation of the chick. Lead caused dose- and time-dependent inhibition of contractions induced by vagal stimulation, transmural stimulation and externally applied acetylcholine (ACh). Vagally evoked contraction was much more sensitive to the inhibitory action of lead than the contractile response to ACh. The lower the frequency of transmural stimulation, or the lower the concentration of ACh was applied, the greater the inhibitory action of lead on the evoked smooth muscle contraction. The results suggest that proventricular impaction occurring in lead poisoning results from the pre- and postsynaptic inhibition of the vagus nerve-smooth muscle transmission.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/2472
Appears in Collections:Japanese Journal of Veterinary Research > Volume 42, Number 3-4

Submitter: 獣医学部図書室

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