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HYPERPLASIA OF BROWN ADIPOSE TISSUE AFTER CHRONIC STIMULATION OF β3-ADRENERGIC RECEPTOR IN RATS

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Please use this identifier to cite or link to this item:https://doi.org/10.14943/jjvr.42.3-4.137

Title: HYPERPLASIA OF BROWN ADIPOSE TISSUE AFTER CHRONIC STIMULATION OF β3-ADRENERGIC RECEPTOR IN RATS
Authors: NAGASE, Itsuro Browse this author
SASAKI, Noriyasu Browse this author
TSUKAZAKI, Katsumi Browse this author
YOSHIDA, Toshihide Browse this author
MORIMATSU, Masami Browse this author
SAITO, Masayuki Browse this author
Keywords: β3-adrenergic receptor
β3-agonist
Brown adipose tissue
Glucose transporter
Uncoupling protein
Issue Date: 31-Jan-1995
Publisher: The Graduate School of Veterinary Medicine
Journal Title: Japanese Journal of Veterinary Research
Volume: 42
Issue: 3-4
Start Page: 137
End Page: 145
Abstract: When mammals are exposed to a cold environment for a long time, the capacity of nonshivering thermogenesis by brown adipose tissue (BAT) increases in association with the increased expression of some specific proteins and tissue hyperplasia, which are totally dependent on sympathetic innervation to this tissue. To clarify roles of the β-adrenergic mechanism in BAT hyperplasia, the effects of chronic administration of various β-adrenergic agonists on BAT were examined in rats, especially focusing on some agonists to the β3-adrenoceptor which is present specifically in adipocytes. Chronic administration of noradrenaline or isoproterenol for 7-10 days produced a marked increase in the tissue contents of DNA, total protein, mitochondrial uncoupling protein, and insulinregulatable glucose transporter protein. The trophic effects of noradrenaline and isoproterenol were mimicked by chronic administration of β3-adrenergic agonists, such as CL316,243,BRL 26830A, and ICI D7114. These results suggest that the β3-adrenoceptor plays important roles for hyperplasia of BAT, and thereby increasing in the capacity of thermogenesis.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/2475
Appears in Collections:Japanese Journal of Veterinary Research > Volume 42, Number 3-4

Submitter: 獣医学部図書室

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