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Volume 43, Number 2  >

PRELIMINARY EFFICACY TRIAL OF CYMELARSAN IN MICE ARTIFICIALLY INFECTED WITH TRYPANOSOMA BRUCEI BRUCEI ISOLATED FROM A DOG IN ZAMBIA

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.43.2.93

Title: PRELIMINARY EFFICACY TRIAL OF CYMELARSAN IN MICE ARTIFICIALLY INFECTED WITH TRYPANOSOMA BRUCEI BRUCEI ISOLATED FROM A DOG IN ZAMBIA
Authors: SYAKALIMA, Michelo Browse this author
YASUDA, Jun Browse this author
HASHIMOTO, Akira Browse this author
Keywords: Trypanosomiasis
Cymelarsan (Mel Cy)
mice
Issue Date: 22-Sep-1995
Publisher: The Graduate School of Veterinary Medicine
Journal Title: Japanese Journal of Veterinary Research
Volume: 43
Issue: 2
Start Page: 93
End Page: 97
Abstract: An efficacy trial of Cymelarsan on a Zambian strain of Trypanosoma brucei brucei was done. Twenty-five male mice were infected intraperitoneally with 10^6 of T. b. brucei isolated from a dog. Five groups of 5 mice were treated with 0 (control), 0.25, 0.5, 1.0 and 2.0 mg/kg Cymelarsan, respectively. The target was to achieve aparasitaemia for 30 days post-treatment, euthanising those that remained parasitaemic or relapsed before then. The 0.25 and 0.5 mg/kg groups remained parasitaemic although the parasitaemic levels were reduced. The 1.0 mg/kg group had a proportion of aparasitaemic mice. However, all mice in the 2.0 mg/kg group remained aparasitaemic until day 20 when 2 mice relapsed. These resullts suggested that more than 2.0 mg/kg was required to eliminate this strain.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/2514
Appears in Collections:Japanese Journal of Veterinary Research > Volume 43, Number 2

Submitter: 獣医学部図書室

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