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Volume 44, Number 2  >

CHANGES OF SERUM CYTOKINE ACTIVITIES AND OTHER PARAMETERS IN DOGS WITH EXPERIMENTALLY INDUCED ENDOTOXIC SHOCK

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この文献には次のDOIがあります:http://doi.org/10.14943/jjvr.44.2.107

タイトル: CHANGES OF SERUM CYTOKINE ACTIVITIES AND OTHER PARAMETERS IN DOGS WITH EXPERIMENTALLY INDUCED ENDOTOXIC SHOCK
著者: MIYAMOTO, Toru 著作を一覧する
FUJINAGA, Toru 著作を一覧する
YAMASHITA, Kazuto 著作を一覧する
HAGIO, Mitsuyoshi 著作を一覧する
キーワード: dog
endotoxic shock
interleukin-1
interleukin-6
tumor necrosis factor
発行日: 1996年 8月30日
出版者: The Graduate School of Veterinary Medicine
誌名: Japanese Journal of Veterinary Research
巻: 44
号: 2
開始ページ: 107
終了ページ: 118
抄録: To study the relationship of changes of cytokines in endotoxic shock, serum tumor necrosis factor (TNF), interleukin (IL)-1 and IL-6 like activities, together with physiologic and hemodynamic responses, were examined in dogs before and after intravenous administration of lipopolysaccharide (LPS) purified from Escherichia coli in a dose of 500 μg/kg of body weight. The blood endotoxin concentration increased significantly at 30 min after LPS administration, and maintained high levels for 24 hr. Red blood cell counts, hemoglobin concentration and hematocrit values increased at 30 min, and these high values persisted for 24 hr. The platelet count decreased significantly at 30 min, then showed a tendency to recover, but decreased again at 24 hr. Cardiac output, cardiac index and mean arterial pressure showed transient, significant decreases at 15 min, and then returned to the baseline levels by 24 hr. TNF-like activities increased at 30 min, while IL-1-like activities did so between 30 and 60 min. The former reached the maximal levels at 2 hr and the latter at 1.5 hr. Both activities were then hardly detectable from 6 to 24 hr. IL-6-like activities elevated at 1 hr with the peak at 1.5 hr, and remained high until 24 hr.
資料タイプ: bulletin
URI: http://hdl.handle.net/2115/2559
出現コレクション:Volume 44, Number 2

 

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