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Volume 44, Number 2  >

CHANGES OF SERUM CYTOKINE ACTIVITIES AND OTHER PARAMETERS IN DOGS WITH EXPERIMENTALLY INDUCED ENDOTOXIC SHOCK

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.44.2.107

Title: CHANGES OF SERUM CYTOKINE ACTIVITIES AND OTHER PARAMETERS IN DOGS WITH EXPERIMENTALLY INDUCED ENDOTOXIC SHOCK
Authors: MIYAMOTO, Toru Browse this author
FUJINAGA, Toru Browse this author
YAMASHITA, Kazuto Browse this author
HAGIO, Mitsuyoshi Browse this author
Keywords: dog
endotoxic shock
interleukin-1
interleukin-6
tumor necrosis factor
Issue Date: 30-Aug-1996
Publisher: The Graduate School of Veterinary Medicine
Journal Title: Japanese Journal of Veterinary Research
Volume: 44
Issue: 2
Start Page: 107
End Page: 118
Abstract: To study the relationship of changes of cytokines in endotoxic shock, serum tumor necrosis factor (TNF), interleukin (IL)-1 and IL-6 like activities, together with physiologic and hemodynamic responses, were examined in dogs before and after intravenous administration of lipopolysaccharide (LPS) purified from Escherichia coli in a dose of 500 μg/kg of body weight. The blood endotoxin concentration increased significantly at 30 min after LPS administration, and maintained high levels for 24 hr. Red blood cell counts, hemoglobin concentration and hematocrit values increased at 30 min, and these high values persisted for 24 hr. The platelet count decreased significantly at 30 min, then showed a tendency to recover, but decreased again at 24 hr. Cardiac output, cardiac index and mean arterial pressure showed transient, significant decreases at 15 min, and then returned to the baseline levels by 24 hr. TNF-like activities increased at 30 min, while IL-1-like activities did so between 30 and 60 min. The former reached the maximal levels at 2 hr and the latter at 1.5 hr. Both activities were then hardly detectable from 6 to 24 hr. IL-6-like activities elevated at 1 hr with the peak at 1.5 hr, and remained high until 24 hr.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/2559
Appears in Collections:Japanese Journal of Veterinary Research > Volume 44, Number 2

Submitter: 獣医学部図書室

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