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Volume 44, Number 3 >

IMMUNOMODULATIVE EFFECTS OF BOVINE IMMUNODEFICIENCY-LIKE VIRUS (BIV)-INFECTION AND MIXED INFECTION OF BIV AND BOVINE LEUKEMIA VIRUS ON SHEEP

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この文献には次のDOIがあります:http://doi.org/10.14943/jjvr.44.3.153

タイトル: IMMUNOMODULATIVE EFFECTS OF BOVINE IMMUNODEFICIENCY-LIKE VIRUS (BIV)-INFECTION AND MIXED INFECTION OF BIV AND BOVINE LEUKEMIA VIRUS ON SHEEP
著者: HIRAI, Nobuaki 著作を一覧する
KABEYA, Hidenori 著作を一覧する
OHASHI, Kazuhiko 著作を一覧する
SUGIMOTO, Chihiro 著作を一覧する
ONUMA, Misao 著作を一覧する
キーワード: bovine immunodeficiency-like virus
bovine leukemia virus
mixed infection
sheep
発行日: 1996年12月18日
出版者: The Graduate School of Veterinary Medicine
誌名: Japanese Journal of Veterinary Research
巻: 44
号: 3
開始ページ: 153
終了ページ: 163
抄録: Experimental bovine immunodeficiency-like virus (BIV)-infection and mixed infection of BIV and bovine leukemia virus (BLV) were performed on sheep. BIV proviral DNA and anti-BIV antibodies were persistently detected in all BIV-inoculated sheep. A slight increase in lymphocyte counts was observed in BIV-infected sheep, but the percentages of CD4^+ and CD8^+ cells in sheep peripheral blood mononuclear cells (PBMCs) were not significantly changed. A transient decrease in lymphocyte blastogenic response to concanavalin A was observed in two of three BIV-infected sheep at 3-6 months after inoculation. From 6 months after BLV-inoculation to sheep which were previously infected with BIV, the numbers of lymphocytes expressing a tumor-associated antigen (TAA) of bovine leukosis were increased compared to those of a sheep inoculated with BLV alone. The BLV titers in PBMCs and the antibody titers against BLV from sheep infected with both BIV and BLV were higher than those of a sheep inoculated with BLV alone.
資料タイプ: bulletin
URI: http://hdl.handle.net/2115/2567
出現コレクション:Volume 44, Number 3

提供者: 獣医学部図書室

 

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