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Volume 44, Number 3 >

IMMUNOMODULATIVE EFFECTS OF BOVINE IMMUNODEFICIENCY-LIKE VIRUS (BIV)-INFECTION AND MIXED INFECTION OF BIV AND BOVINE LEUKEMIA VIRUS ON SHEEP

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.44.3.153

Title: IMMUNOMODULATIVE EFFECTS OF BOVINE IMMUNODEFICIENCY-LIKE VIRUS (BIV)-INFECTION AND MIXED INFECTION OF BIV AND BOVINE LEUKEMIA VIRUS ON SHEEP
Authors: HIRAI, Nobuaki Browse this author
KABEYA, Hidenori Browse this author
OHASHI, Kazuhiko Browse this author
SUGIMOTO, Chihiro Browse this author →KAKEN DB
ONUMA, Misao Browse this author
Keywords: bovine immunodeficiency-like virus
bovine leukemia virus
mixed infection
sheep
Issue Date: 18-Dec-1996
Publisher: The Graduate School of Veterinary Medicine
Journal Title: Japanese Journal of Veterinary Research
Volume: 44
Issue: 3
Start Page: 153
End Page: 163
Abstract: Experimental bovine immunodeficiency-like virus (BIV)-infection and mixed infection of BIV and bovine leukemia virus (BLV) were performed on sheep. BIV proviral DNA and anti-BIV antibodies were persistently detected in all BIV-inoculated sheep. A slight increase in lymphocyte counts was observed in BIV-infected sheep, but the percentages of CD4^+ and CD8^+ cells in sheep peripheral blood mononuclear cells (PBMCs) were not significantly changed. A transient decrease in lymphocyte blastogenic response to concanavalin A was observed in two of three BIV-infected sheep at 3-6 months after inoculation. From 6 months after BLV-inoculation to sheep which were previously infected with BIV, the numbers of lymphocytes expressing a tumor-associated antigen (TAA) of bovine leukosis were increased compared to those of a sheep inoculated with BLV alone. The BLV titers in PBMCs and the antibody titers against BLV from sheep infected with both BIV and BLV were higher than those of a sheep inoculated with BLV alone.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/2567
Appears in Collections:Japanese Journal of Veterinary Research > Volume 44, Number 3

Submitter: 獣医学部図書室

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