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Volume 45, Number 3 >

Ultrasonography, Biochemical and Hematological Profiles in Liver Disease Caused by Intravenous Administration of Dimethylnitrosamine in Dogs

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.45.3.153

Title: Ultrasonography, Biochemical and Hematological Profiles in Liver Disease Caused by Intravenous Administration of Dimethylnitrosamine in Dogs
Authors: MWANZA, Timothy Browse this author
MIYAMOTO, Toru Browse this author
OKUMURA, Masahiro Browse this author →KAKEN DB
KADOSAWA, Tsuyoshi Browse this author
FUJINAGA, Toru Browse this author
Keywords: cirrhosis
dimethylnitrosamine
dog
liver enzymes
ultrasonography
Issue Date: 28-Nov-1997
Publisher: The Graduate School of Veterinary Medicine
Journal Title: Japanese Journal of Veterinary Research
Volume: 45
Issue: 3
Start Page: 153
End Page: 161
Abstract: The results of liver function tests and ultrasonographical findings were analysed in 7 dogs that were intravenously injected dimethylnitrosamine (DMNA 2 mg/kg body weight) on 2 consecutive days each week for 10 weeks. Typical clinical signs and similar changes in liver enzyme concentrations that develop in dogs with natural cirrhosis were observed in this canine model. Severe anaemia and a significant reduction in the platelet numbers occurred in the dogs that died in the 5th week, while in all the other dogs these parameters decreased slightly. Serum total protein and the albumin/ globulin ratio decreased gradually while the alkaline phosphatase, alanine amino transferase, aspartate amino transferase and gamma glutamyl transpeptidase activities increased significantly (p<0.05) in all dogs after beginning the administration of DMNA. Ultrasound findings of a coarsened and heterogeneous echo pattern with increased echogenicity that are characteristic of canine cirrhosis were noticed at the same time when the changes in liver enzymes became evident. Present results suggest that ultrasonography in conjunction with liver function tests may be useful in the evaluation of experimentally induced liver cirrhosis.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/2602
Appears in Collections:Japanese Journal of Veterinary Research > Volume 45, Number 3

Submitter: 獣医学部図書室

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