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Extensive Accumulation of Influenza Virus NS1 Protein in the Nuclei Causes Effective Viral Growth in Vero Cells

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Title: Extensive Accumulation of Influenza Virus NS1 Protein in the Nuclei Causes Effective Viral Growth in Vero Cells
Authors: Ozaki, Hiroichi Browse this author
Kida, Hiroshi Browse this author →KAKEN DB
Keywords: Influenza virus
NS1
Nuclear localization
Issue Date: 2007
Publisher: Center for Academic Publications Japan
Journal Title: Microbiology and Immunology
Volume: 51
Issue: 5
Start Page: 577
End Page: 580
PMID: 17579268
Abstract: We previously showed that modified A/Puerto Rico/8/34 (PR8) influenza master strain had improved viral rescue and growth properties in African green monkey kidney (Vero) cell line by introducing NS gene of Vero-adapted A/England/1/53 (vaEng53). In the present study, it was found that the NS1 protein derived from vaEng53 was extensively accumulated in the nuclei than that of PR8. This accumulation was caused by 7 amino acid differences in C-terminal region of NS1 protein. These results suggest that specific accumulation of NS1 protein may contribute to efficient viral replication in Vero cells.
Type: article (author version)
URI: http://hdl.handle.net/2115/26122
Appears in Collections:創成研究機構 (Creative Research Institution) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 尾崎 弘一

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