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Extensive Accumulation of Influenza Virus NS1 Protein in the Nuclei Causes Effective Viral Growth in Vero Cells
| Title: | Extensive Accumulation of Influenza Virus NS1 Protein in the Nuclei Causes Effective Viral Growth in Vero Cells |
| Authors: | Ozaki, Hiroichi Browse this author | | Kida, Hiroshi Browse this author →KAKEN DB |
| Keywords: | Influenza virus | | NS1 | | Nuclear localization |
| Issue Date: | 2007 |
| Publisher: | Center for Academic Publications Japan |
| Journal Title: | Microbiology and Immunology |
| Volume: | 51 |
| Issue: | 5 |
| Start Page: | 577 |
| End Page: | 580 |
| PMID: | 17579268 |
| Abstract: | We previously showed that modified A/Puerto Rico/8/34 (PR8) influenza master strain had improved viral rescue and growth properties in African green monkey kidney (Vero) cell line by introducing NS gene of Vero-adapted A/England/1/53 (vaEng53). In the present study, it was found that the NS1 protein derived from vaEng53 was extensively accumulated in the nuclei than that of PR8. This accumulation was caused by 7 amino acid differences in C-terminal region of NS1 protein. These results suggest that specific accumulation of NS1 protein may contribute to efficient viral replication in Vero cells. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/26122 |
| Appears in Collections: | 創成研究機構 (Creative Research Institution) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 尾崎 弘一
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