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Volume 46, Number 1 >

Trisomy 8 does not affect differentiative potential in a murine parthenogenetic embryonic stem cell line

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この文献には次のDOIがあります:http://doi.org/10.14943/jjvr.46.1.29

タイトル: Trisomy 8 does not affect differentiative potential in a murine parthenogenetic embryonic stem cell line
著者: PARK, Jong-Im 著作を一覧する
YOSHIDA, Ikuya 著作を一覧する
TADA, Takashi 著作を一覧する
TAKAGI, Nobuo 著作を一覧する
TAKAHASHI, Yoshiyuki 著作を一覧する
KANAGAWA, Hiroshi 著作を一覧する
キーワード: embryonic stem cells
parthenogenesis
transfection
trisomy 8
発行日: 1998年 5月30日
出版者: The Graduate School of Veterinary Medicine
誌名: Japanese Journal of Veterinary Research
巻: 46
号: 1
開始ページ: 29
終了ページ: 35
抄録: Murine parthenogenetic embryonic stem (ES) cell lines expressing lac Z reporter gene were isolated after co-transfection with lac Z reporter gene (pENL) and neo^R gene (pSTneo) to TMA-48P cell line of 129/Sv origin. Karyotype analyses showed that all of four transfected cell lines examined contained 41 chromosomes with trisomy 8. Bacterial neo^R transgene required for G418 selection were integrated into several chromosomes including chromosome 8. Histological studies of teratomas formed in syngenic mice and embryoid bodies grown in vitro showed that the differentiative potential remained almost identical in chromosomally normal parental cell line and its derivative cell lines trisomic for chromosome 8.
資料タイプ: bulletin
URI: http://hdl.handle.net/2115/2636
出現コレクション:Volume 46, Number 1

提供者: 獣医学部図書室

 

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