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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
Japanese Journal of Veterinary Research >
Volume 47, Number 1-2 >
Protective effects of intranasal vaccination with plasmid encoding pseudorabies virus glycoprotein B in mice
| Title: | Protective effects of intranasal vaccination with plasmid encoding pseudorabies virus glycoprotein B in mice |
| Authors: | TAKADA, Ayato Browse this author →KAKEN DB | | OKAZAKI, Katsunori Browse this author | | KIDA, Hiroshi Browse this author →KAKEN DB |
| Keywords: | DNA vaccine | | intranasal vaccination | | mucosal immunity | | pseudorabies virus |
| Issue Date: | 31-Aug-1999 |
| Publisher: | The Graduate School of Veterinary Medicine |
| Journal Title: | Japanese Journal of Veterinary Research |
| Volume: | 47 |
| Issue: | 1-2 |
| Start Page: | 25 |
| End Page: | 33 |
| Abstract: | Intranasal administration of plasmid DNA encoding glycoprotein B of pseudorabies virus into mice induced both serum and secretory antibody responses. These mice resisted intranasal challenge with lethal dose of the virus, but did not intraperitoneal challenge. On the other hand, intramuscular injection of the plasmid induced less secretory and higher serum antibody responses than those of intranasally vaccinated mice. None of them was protected from virus challenge. The present results suggest that administration of plasmid DNA encoding glycoprotein B by respiratory mucosal route generates local secretory antibodies which serve to protect animals from pseudorabies virus infection. |
| Type: | bulletin (article) |
| URI: | http://hdl.handle.net/2115/2726 |
| Appears in Collections: | Japanese Journal of Veterinary Research > Volume 47, Number 1-2
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Submitter: 高田 礼人
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