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Volume 47, Number 1-2 >

Protective effects of intranasal vaccination with plasmid encoding pseudorabies virus glycoprotein B in mice

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.47.1-2.25

Title: Protective effects of intranasal vaccination with plasmid encoding pseudorabies virus glycoprotein B in mice
Authors: TAKADA, Ayato Browse this author →KAKEN DB
OKAZAKI, Katsunori Browse this author
KIDA, Hiroshi Browse this author →KAKEN DB
Keywords: DNA vaccine
intranasal vaccination
mucosal immunity
pseudorabies virus
Issue Date: 31-Aug-1999
Publisher: The Graduate School of Veterinary Medicine
Journal Title: Japanese Journal of Veterinary Research
Volume: 47
Issue: 1-2
Start Page: 25
End Page: 33
Abstract: Intranasal administration of plasmid DNA encoding glycoprotein B of pseudorabies virus into mice induced both serum and secretory antibody responses. These mice resisted intranasal challenge with lethal dose of the virus, but did not intraperitoneal challenge. On the other hand, intramuscular injection of the plasmid induced less secretory and higher serum antibody responses than those of intranasally vaccinated mice. None of them was protected from virus challenge. The present results suggest that administration of plasmid DNA encoding glycoprotein B by respiratory mucosal route generates local secretory antibodies which serve to protect animals from pseudorabies virus infection.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/2726
Appears in Collections:Japanese Journal of Veterinary Research > Volume 47, Number 1-2

Submitter: 高田 礼人

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