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Postnatal changes in Rho and Rho-related proteins in the mouse brain

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Title: Postnatal changes in Rho and Rho-related proteins in the mouse brain
Authors: KOMAGOME, Rika Browse this author
KIMURA, Kazuhiro Browse this author →KAKEN DB
SAITO, Masayuki Browse this author
Keywords: brain
postnatal development
Issue Date: 29-Feb-2000
Publisher: The Graduate School of Veterinary Medicine
Journal Title: Japanese Journal of Veterinary Research
Volume: 47
Issue: 3-4
Start Page: 127
End Page: 133
Abstract: To provide information on the role of Rho, a GTP-binding protein, in postnatal development of the brain cells, the change in the levels of Rho protein and Rho-related proteins was examined in the brain of mice for two weeks after birth, in parallel with the changes in the activity of marker enzymes for neuronal and glial cells. The activities of acetylcholine esterase and choline acetyltransferase of whole brain homogenate, both of which are neuronal marker enzymes, were progressively increased in an age-dependent manner. The activity of 2', 3'-cyclic nucleotide 3'-phosphohydrolase, a glial marker enzyme, increased markedly between one and two weeks after birth. In contrast, the levels of RhoA and RhoB in the membrane fraction were decreased during the postnatal period. The amount of Rho GDP dissociation inhibitor, a regulatory protein for Rho, was unchanged, while those of Rho target proteins, Rock-2 and citron, were gradually increased. Since the inactivation of Rho is known to induce neurite extension and neuronal and glial differentiation in vitro, our results suggest that the Rho signalling pathway plays a regulatory role in the postnatal differentiation of neuronal and glial cells in vivo.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 47, Number 3-4

Submitter: 獣医学部図書室

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