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Volume 47, Number 3-4 >

Dose dependency of prednisolone on the establishment of Echinococcus multilocularis infection in an alternative definitive host, Mongolian gerbil

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この文献には次のDOIがあります:http://doi.org/10.14943/jjvr.47.3-4.145

タイトル: Dose dependency of prednisolone on the establishment of Echinococcus multilocularis infection in an alternative definitive host, Mongolian gerbil
著者: MATSUO, Kayoko 著作を一覧する
TADA, Tomohiro 著作を一覧する
NONAKA, Nariaki 著作を一覧する
OKU, Yuzaburo 著作を一覧する
KAMIYA, Masao 著作を一覧する
キーワード: Echinococcus multilocularis
Mongolian gerbil
prednisolone tertiary-butylacetate
発行日: 2000年 2月29日
出版者: The Graduate School of Veterinary Medicine
誌名: Japanese Journal of Veterinary Research
巻: 47
号: 3-4
開始ページ: 145
終了ページ: 149
抄録: This study revealed the dose dependency of prednisolone tertiary-butylacetate (PTBA) treatment on the establishment of Echinococcus multilocularis in the small intestine of Mongolian gerbil (Meriones unguiculatus) and that some of the physiological parameters of host were correlated with the doses of PTBA and establishment of the worm. Twenty Mongolian gerbils were divided into 5 groups, according to the doses of PTBA ; 0mg, 0.5mg, 2mg, 5mg and 10mg per head. All animals were injected intraperitoneally with PTBA every other day from 6 days before to 6 days after infection. Doses of PTBA and the number of worms recovered at 7 days post-infection showed a positive correlation (r=0.929, P<0.0001). The increase of total protein (TP) and the decrease of the percentage of lymphocytes in the peripheral leukocytes were dependent on doses of PTBA (TP : r=0.811, P<0.0001, percentage of lymphocyte : r=-0.92, P<0.0001). The TP and the percentage of lymphocyte also correlated with the number of worms recovered (TP : r=0.617, P=0.0049 ; percentage of lymphocyte : r=-0.800, P<0.0001).
資料タイプ: bulletin
URI: http://hdl.handle.net/2115/2788
出現コレクション:Volume 47, Number 3-4

 

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