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Volume 47, Number 3-4 >

Dose dependency of prednisolone on the establishment of Echinococcus multilocularis infection in an alternative definitive host, Mongolian gerbil

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.47.3-4.145

Title: Dose dependency of prednisolone on the establishment of Echinococcus multilocularis infection in an alternative definitive host, Mongolian gerbil
Authors: MATSUO, Kayoko Browse this author
TADA, Tomohiro Browse this author
NONAKA, Nariaki Browse this author
OKU, Yuzaburo Browse this author
KAMIYA, Masao Browse this author
Keywords: Echinococcus multilocularis
Mongolian gerbil
prednisolone tertiary-butylacetate
Issue Date: 29-Feb-2000
Publisher: The Graduate School of Veterinary Medicine
Journal Title: Japanese Journal of Veterinary Research
Volume: 47
Issue: 3-4
Start Page: 145
End Page: 149
Abstract: This study revealed the dose dependency of prednisolone tertiary-butylacetate (PTBA) treatment on the establishment of Echinococcus multilocularis in the small intestine of Mongolian gerbil (Meriones unguiculatus) and that some of the physiological parameters of host were correlated with the doses of PTBA and establishment of the worm. Twenty Mongolian gerbils were divided into 5 groups, according to the doses of PTBA ; 0mg, 0.5mg, 2mg, 5mg and 10mg per head. All animals were injected intraperitoneally with PTBA every other day from 6 days before to 6 days after infection. Doses of PTBA and the number of worms recovered at 7 days post-infection showed a positive correlation (r=0.929, P<0.0001). The increase of total protein (TP) and the decrease of the percentage of lymphocytes in the peripheral leukocytes were dependent on doses of PTBA (TP : r=0.811, P<0.0001, percentage of lymphocyte : r=-0.92, P<0.0001). The TP and the percentage of lymphocyte also correlated with the number of worms recovered (TP : r=0.617, P=0.0049 ; percentage of lymphocyte : r=-0.800, P<0.0001).
Type: bulletin (article)
URI: http://hdl.handle.net/2115/2788
Appears in Collections:Japanese Journal of Veterinary Research > Volume 47, Number 3-4

Submitter: 獣医学部図書室

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